4,6-Dimethyl-3-hydroxypyridine

Base Information

• Chemical Name: 4,6-Dimethyl-3-hydroxypyridine
• CAS No.: 27296-77-1
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2933399090
• ChEMBL ID: CHEMBL424648
• DSSTox Substance ID: DTXSID50567512
• Nikkaji Number: J2.799.734A
• Wikidata: Q82453414
• Mol file: 27296-77-1.mol

Synonyms:4,6-Dimethyl-3-hydroxypyridine;27296-77-1;4,6-Dimethylpyridin-3-ol;2,4-Dimethyl-5-hydroxypyridine;3-Pyridinol,4,6-dimethyl-;3-Hydroxy-4,6-dimethylpyridine;CHEMBL424648;SCHEMBL1128276;DTXSID50567512;4-methyl-5-hydroxy methylpyridine;OICQOTPIZHVKQL-UHFFFAOYSA-N;MFCD08272851;AB44457;4,6-dimethyl-3-hydroxypyridine, AldrichCPR;CS-0205430;W-202150

Chemical Property of 4,6-Dimethyl-3-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 302.87 °C at 760 mmHg
• Flash Point: 136.971 °C
• PSA: 33.12000
• Density: 1.084g/cm³
• LogP: 1.40400
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 94.9

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dimethyl-5-hydroxypyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1O)C

Technology Process of 4,6-Dimethyl-3-hydroxypyridine

There total 3 articles about 4,6-Dimethyl-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethylpyridine N-oxide (1122-45-8) + acetic anhydride (108-24-7) → (4-methyl-2-pyridinyl)methanol (42508-74-7) + (2-methylpyridin-4-yl)methanol (105250-16-6) + 2,4-dimethyl-5-hydroxypyridine (27296-77-1)

Guidance literature:

anschliessend Erhitzen mit wss. Salzsaeure;

Reference yield:

5-amino-2,4-dimethylpyridine (1193-71-1) → 2,4-dimethyl-5-hydroxypyridine (27296-77-1) + 5-methyl-3H-pyrazolo[3,4-c]pyridine (860410-54-4)

Guidance literature:

With sulfuric acid; Diazotization_.und anschliessenden Erwaermen;

Reference yield:

5-amino-2,4-dimethylpyridine (1193-71-1) + sulfuric acid (7664-93-9) → 2,4-dimethyl-5-hydroxypyridine (27296-77-1) + 5-methyl-3H-pyrazolo[3,4-c]pyridine (860410-54-4)

Guidance literature:

upstream raw materials:

2,4-dimethylpyridine N-oxide

acetic anhydride

5-amino-2,4-dimethylpyridine

sulfuric acid

Downstream raw materials:

2-amino-3-hydroxy-4,6-dimethylpyridine

2,4-dimethyl-5-hydroxypyridine N-oxide