4(1H)-Pteridinone,2-amino-7-ethyl-(9CI)

Base Information

• Chemical Name: 4(1H)-Pteridinone,2-amino-7-ethyl-(9CI)
• CAS No.: 25716-33-0
• Molecular Formula: C8H9 N5 O
• Molecular Weight: 191.192
• Hs Code.: 2933990090
• Mol file: 25716-33-0.mol

Synonyms:4(1H)-Pteridinone,2-amino-7-ethyl- (9CI); 4(3H)-Pteridinone, 2-amino-7-ethyl- (8CI)

Chemical Property of 4(1H)-Pteridinone,2-amino-7-ethyl-(9CI)

Chemical Property:

• Melting Point: >360 °C (decomp)
• Boiling Point: 345.1±25.0 °C(Predicted)
• PKA: 2.62±0.20(Predicted)
• PSA: 98.54000
• Density: 1 +-.0.1 g/cm3(Predicted)
• LogP: 0.20010

Purity/Quality:

99%min ^*data from raw suppliers

2-Amino-7-ethyl-4(3H)-pteridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-7-ethyl-4(3H)-pteridinone is an impurity of Folic Acid (F680300), a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Technology Process of 4(1H)-Pteridinone,2-amino-7-ethyl-(9CI)

There total 7 articles about 4(1H)-Pteridinone,2-amino-7-ethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4,5-triaminopyrimidin-6(1H)-one sulfate monohydrate (35011-47-3) + 1-chloro-1-benzamido-2-butanone (88297-82-9) → 7-ethylpteridine (25716-33-0)

Guidance literature:

With sodium hydrogencarbonate; tiolacetic acid; In ethanol; at 100 ℃; for 2h;

DOI:10.1007/BF00956526

Reference yield: 50.0%

1-Piperidino butan-2-one (23588-52-5) + 2,5,6-triamino-3,4-dihydro-4-pyrimidinone (1004-75-7) → 7-ethylpteridine (25716-33-0)

Guidance literature:

With piperidine; at 20 ℃; for 150h;

DOI:10.1007/BF01094658

Reference yield:

hexyl-methyl-ketone (111-13-7) + butanone (78-93-3) → 7-ethylpteridine (25716-33-0) + 6,7-Dimethylpterin (611-55-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1007/BF00960274

upstream raw materials:

1-Piperidino butan-2-one

2,5,6-triamino-3,4-dihydro-4-pyrimidinone

1-N-phthalimidobutan-2-one

2,4,5-triaminopyrimidin-6(1H)-one sulfate monohydrate

Refernces

• 1、 Waring,Armarego. "The dihydropteridine reductase (human brain) activity of some lipophilic quinonoid dihydropterins". . p. 83 - 90. Retrieved 2007/10/02.
• 2、 Zav'yalov, S. I.,Zavozin, A. G.,Ezhova, G. I.. "REGIOSELECTIVE SYNTHESIS OF SUBSTITUTED PTERIDINES". . p. 2183 - 2185. Retrieved 2007/10/02.