2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate

Base Information

• Chemical Name: 2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate
• CAS No.: 1415503-66-0
• Molecular Formula: C₁₂H₁₇ClO₂
• Molecular Weight: 228.719
• Mol file: 1415503-66-0.mol

Synonyms:2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate

Chemical Property of 2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate

There total 1 articles about 2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

piperitone (89-81-6,6091-52-7) + Chloroacetic anhydride (541-88-8) → 2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate (1415503-66-0)

Guidance literature:

piperitone; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.5h; Inert atmosphere;

Chloroacetic anhydride; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; for 1h; Inert atmosphere;

DOI:10.1021/ol3027363

Reference yield: 99.0%

2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate (1415503-66-0) → (-)-piperitone (4573-50-6)

Guidance literature:

With N-9-anthracenylmethylcinchonidinium chloride; potassium hydroxide; 2-chloro-ethanol; In chloroform; 1,3,5-trimethyl-benzene; at -40 ℃; for 24h; Reagent/catalyst; Concentration; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol3027363

Reference yield:

2-isopropyl-5-methylcyclohexa-1,5-dien-1-yl 2-chloroacetate (1415503-66-0) → (S)-(+)-piperitone (4573-50-6,6091-52-7,89-81-6,6091-50-5) + (-)-piperitone (4573-50-6)

Guidance literature:

With C₃₄H₃₃N₂O⁽¹⁺⁾*C₂H₂F₃O^(1-); potassium hydroxide; In chloroform; at -40 ℃; for 7h; Overall yield = 72 %; Overall yield = 11 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol3027363

upstream raw materials:

piperitone

Chloroacetic anhydride

Downstream raw materials:

(-)-piperitone

(S)-(+)-piperitone

Refernces