Acetic acid, 2-(4-aminophenoxy)-, ethyl ester

Base Information

• Chemical Name: Acetic acid, 2-(4-aminophenoxy)-, ethyl ester
• CAS No.: 20485-38-5
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Mol file: 20485-38-5.mol

Synonyms:Aceticacid, (4-aminophenoxy)-, ethyl ester (9CI); Acetic acid, (p-aminophenoxy)-,ethyl ester (7CI,8CI); 4-(Ethoxycarbonylmethoxy)aniline; 4-Aminophenoxyaceticacid ethyl ester; Ethyl (4-aminophenoxy)acetate

Chemical Property of Acetic acid, 2-(4-aminophenoxy)-, ethyl ester

Chemical Property:

• PSA: 61.55000
• LogP: 1.79190

Purity/Quality:

98% ^*data from raw suppliers

ethyl2-(4-aminophenoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, 2-(4-aminophenoxy)-, ethyl ester

There total 8 articles about Acetic acid, 2-(4-aminophenoxy)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 4-nitrophenoxyacetate (19076-89-2) → ethyl 2-(4-aminophenoxy)acetate (20485-38-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

DOI:10.1021/jm2002525

Reference yield: 27.5%

4-amino-phenol (123-30-8) + ethyl bromoacetate (105-36-2) → ethyl 2-(4-aminophenoxy)acetate (20485-38-5)

Guidance literature:

4-amino-phenol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ja048543m

Reference yield:

methyl 2-(4-nitrophenoxy)acetate (19786-48-2) → ethyl 2-(4-aminophenoxy)acetate (20485-38-5)

Guidance literature:

palladium; In ethyl acetate;

upstream raw materials:

4-aminophenoxyacetic acid

4-amino-phenol

chloroacetic acid ethyl ester

ethyl bromoacetate

Downstream raw materials:

(4-N,N-bis(2-hydroxyethyl)phenoxy)acetic acid ethyl ester

[4-(4-Bromo-benzenesulfonylamino)-phenoxy]-acetic acid ethyl ester

(R)-{4-[{2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino]phenoxy}acetic acid ethyl ester

4-(benzenesulphonylamino)-phenoxyacetic acid

Refernces

• 1、 -. "GK and PPAR dual agonist activity aryl urea derivatives". Paragraph 0090; 0091. . Retrieved 2016/12/01.
• 2、 -. "CONJUGATES AND SMALL MOLECULES WHICH INTERACT WITH THE CD16A RECEPTOR". Paragraph 0040; 0041. . Retrieved 2015/12/08.