α,α-bis(4-methylphenyl)acetophenone

Base Information

• Chemical Name: α,α-bis(4-methylphenyl)acetophenone
• CAS No.: 56074-58-9
• Molecular Formula: C₂₂H₂₀O
• Molecular Weight: 300.4
• Mol file: 56074-58-9.mol

Synonyms:α,α-bis(4-methylphenyl)acetophenone

Chemical Property of α,α-bis(4-methylphenyl)acetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-bis(4-methylphenyl)acetophenone

There total 21 articles about α,α-bis(4-methylphenyl)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

bis(p-methylphenyl)-methanone (611-97-2) + N-benzoylbenzimidazole (62573-86-8) → α,α-bis(4-methylphenyl)acetophenone (56074-58-9)

Guidance literature:

With samarium; titanium tetrachloride; In tetrahydrofuran; for 24h; Heating;

Reference yield: 74.0%

1-methyl-4-nitrobenzene (99-99-0) + 1-phenyl-2-p-tolylethanone (2430-99-1) → α,α-bis(4-methylphenyl)acetophenone (56074-58-9)

Guidance literature:

With potassium phosphate; bis(acetylacetonato)palladium(II); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; In cyclohexane; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04104

Reference yield: 70.0%

4-tolyl iodide (624-31-7) + 1-phenyl-2-p-tolylethanone (2430-99-1) → α,α-bis(4-methylphenyl)acetophenone (56074-58-9)

Guidance literature:

With copper(l) iodide; bathophenanthroline; caesium carbonate; In tert-butyl alcohol; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201206024

upstream raw materials:

phenyl-di-p-tolyl-acetaldehyde

Di-p-tolyl-acetylchlorid

diphenyl cadmium

2-phenyl-1,1-di-p-tolyl-ethane-1,2-diol

Downstream raw materials:

4,4'-dimethyldiphenylmethane

benzoic acid

4-nitro-benzoic acid-(1-phenyl-2,2-di-p-tolyl-ethyl ester)

Refernces

• 1、 -. "PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS". Paragraph 0173-0182; 0228-0236. . Retrieved 2015/06/24.
• 2、 Danoun, Grégory,Tlili, Anis,Monnier, Florian,Taillefer, Marc. "Direct copper-catalyzed α-arylation of benzyl phenyl ketones with aryl iodides: Route towards tamoxifen". supporting information. p. 12815 - 12819. Retrieved 2013/02/22.