BENZOYL PEROXIDE

Base Information

• Chemical Name: BENZOYL PEROXIDE
• CAS No.: 2685-64-5
• Molecular Formula: C14H10O4
• Molecular Weight: 425.363
• Hs Code.: 2916320000
• Mol file: 2685-64-5.mol

Synonyms:LUPEROX A70S;LUPEROX A75;LUPEROX A75FP;LUPEROX AFR40;LUPEROX ATC50;BENZOPEROXIDE;BENZOYL DIOXIDE;BENZOYL BENZENECARBOPEROXOATE

Chemical Property of BENZOYL PEROXIDE

Chemical Property:

• Melting Point: 105 °C(lit.)
• Boiling Point: 349.747 °C at 760 mmHg
• Flash Point: 154.239 °C
• PSA: 52.60000
• Density: 1.254 g/cm³
• LogP: 2.61540
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): O,N,Xn
• Hazard Codes: O,Xn,N
• Statements: 8-36/37/38-43-40-36-7
• Safety Statements: 53-17-26-36/37-45-60-3/7-14

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOYL PEROXIDE

There total 5 articles about BENZOYL PEROXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3β-acetoxy-5-bromo-6β-hydroxy-5α-androstan-17-one (4229-69-0) → 5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate (2685-64-5)

Guidance literature:

With iodine; lead(IV) tetraacetate; In benzene; for 0.5h; Reflux;

DOI:10.1016/j.tetlet.2016.07.067

Reference yield:

prasterone acetate (853-23-6) → 5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate (2685-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 54.3 percent / NBA, 70 percent HClO₄ / dioxane; H₂O / 2 h / Ambient temperature

2: Pb(AcO)4, I₂, CaCO₃ / cyclohexane / 1 h / Heating; Irradiation

With lead(IV) acetate; perchloric acid; iodine; calcium carbonate; N-bromoacetamide; In 1,4-dioxane; cyclohexane; water;

DOI:10.1016/S0040-4020(01)87452-4

Reference yield:

3β-acetoxy-5-bromo-6β-hydroxy-5α-androstan-17-one (4229-69-0) → 5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate (2685-64-5) + 3β-acetoxy-5β,6β-epoxyandrostan-17-one (6585-68-8)

Guidance literature:

With lead(IV) acetate; iodine; In tetrachloromethane; acetic acid; for 0.0833333h; Product distribution; Mechanism; Heating; Irradiation; dependence on solvent, light intensity; further without light;

DOI:10.1016/0039-128X(81)90003-9

upstream raw materials:

3β-acetoxy-5-bromo-6β-hydroxy-5α-androstan-17-one

prasterone acetate

Downstream raw materials:

3β,19-dihydroxy-5-androsten-17-one

3β,16α,19-trihydroxy-5-androsten-17-one

3β-acetoxy-19-hydroxyandrost-5-en-17-one

17β,19-dihydroxy-androst-4-en-3-one 17-benzoate

Refernces

• 1、 Costa, Saul C. P.,Moreno, M. J. S. Miranda,Saì? e Melo, M. Luisa,Campos Neves, Andreì? S.. "Ultrasound assisted remote functionalization of non-activated carbon atoms: Efficient in situ formation of tetrahydrofurans by sonolysis of bromohydrins with (diacetoxyiodo)benzene/I2". . p. 8711 - 8714. Retrieved 1999.
• 2、 -. "COMPOUNDS AND METHODS FOR TREATING NEOPLASIA". Page/Page column 94. . Retrieved 2012/02/13.