3-Butenamide

Base Information

• Chemical Name: 3-Butenamide
• CAS No.: 28446-58-4
• Molecular Formula: C4H7 N O
• Molecular Weight: 85.1057
• Hs Code.: 2924199090
• Mol file: 28446-58-4.mol

Synonyms:Allylamide;Vinylacetamide

Chemical Property of 3-Butenamide

Chemical Property:

• Vapor Pressure: 0.224mmHg at 25°C
• Melting Point: 66-68°C
• Refractive Index: 1.44
• Boiling Point: 207.5°C at 760 mmHg
• PKA: 16.26±0.40(Predicted)
• Flash Point: 79.3°C
• PSA: 43.09000
• Density: 0.94g/cm³
• LogP: 0.74810
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%, ^*data from raw suppliers

3-Butenamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Butenamide

There total 3 articles about 3-Butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2-nitroaniline (96-96-8) → hydrogen azide (7782-79-8) + ethyl isopropyl ketone (565-69-5) + n-hexan-3-one (589-38-8) + but-3-enamide (28446-58-4) + (2E,4Z)-3-methoxyhexa-2,4-dienedinitrile (1789-46-4) + acetic acid (64-19-7,77671-22-8) + cyanoacetic acid (372-09-8) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) + Methacrylamide (79-39-0) + ethyl cyanate (627-48-5)

Guidance literature:

With ferrous(II) sulfate heptahydrate; dihydrogen peroxide; at 25 ℃; for 0.0833333h; pH=6.12; pH-value; Kinetics;

DOI:10.1039/c8ra00627j

Reference yield:

but-3-enenitrile (109-75-1) → but-3-enoic acid (625-38-7) + but-3-enamide (28446-58-4)

Guidance literature:

With potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT₂ EC 3.5.5.1; In water; at 30 ℃; for 14h; pH=7.15; Title compound not separated from byproducts;

DOI:10.1016/j.tet.2006.04.069

Reference yield:

4-iodomethyl-1-(t-butyldimethylsilyl)-2-azetidinone (85390-50-7) → but-3-enamide (28446-58-4) + crotonamide (23350-58-5)

Guidance literature:

With disodium tetracarbonylferrate; In tetrahydrofuran; at 25 ℃; for 3h;

DOI:10.1021/jo00160a031

upstream raw materials:

4-iodomethyl-1-(t-butyldimethylsilyl)-2-azetidinone

but-3-enenitrile

4-methoxy-2-nitroaniline

Downstream raw materials:

2-propenyl ammonium tosylate

crotonamide

5,6-Dihydro-6-phenyl-2(1H)-pyridinone

Refernces

• 1、 Mukherjee, Chandrani,Zhu, Dunming,Biehl, Edward R.,Parmar, Rajiv R.,Hua, Ling. "Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation". . p. 6150 - 6154. Retrieved 2007/10/03.