2-(2-methylpheny)lcyclopentanone

Base Information

• Chemical Name: 2-(2-methylpheny)lcyclopentanone
• CAS No.: 52086-32-5
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.243
• Mol file: 52086-32-5.mol

Synonyms:2-(2-methylpheny)lcyclopentanone

Chemical Property of 2-(2-methylpheny)lcyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methylpheny)lcyclopentanone

There total 3 articles about 2-(2-methylpheny)lcyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cyclobutanone (1191-95-3) + 1-(diazomethyl)-2-methylbenzene (698-20-4) → 2-(2-methylpheny)lcyclopentanone (52086-32-5)

Guidance literature:

cyclobutanone; With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

1-(diazomethyl)-2-methylbenzene; In dichloromethane; toluene; at -78 - 0 ℃; Inert atmosphere;

DOI:10.1055/s-0031-1289650

Reference yield: 44.0%

2-methylphenyl bromide (95-46-5) + cyclopentanone (120-92-3) → 2-(2-methylpheny)lcyclopentanone (52086-32-5)

Guidance literature:

With pyrrolidine; tert-Octylamine; sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine; In 1,4-dioxane; at 110 ℃; for 18h; chemoselective reaction; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1002/anie.201510638

Reference yield:

C12H16O → 2-(2-methylpheny)lcyclopentanone (52086-32-5)

Guidance literature:

With aluminum oxide; pyridinium chlorochromate; In toluene; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2014.06.014

upstream raw materials:

2-methylphenyl bromide

cyclopentanone

cyclobutanone

1-(diazomethyl)-2-methylbenzene

Downstream raw materials:

(1R,2R)-2-o-tolyl-cyclopentylamine

Refernces

• 1、 Zhao, Binlin,Tan, Hui,Chen, Cheng,Jiao, Ning,Shi, Zhuangzhi. "Photoinduced C—C Bond Cleavage and Oxidation of Cycloketoxime Esters". supporting information. p. 995 - 999. Retrieved 2018/09/25.
• 2、 Arnold, Nicola,Beattie, David,Bradley, Michelle,Brearley, Andrew,Brown, Lyndon,Charlton, Steven J.,Fairhurst, Robin A.,Farr, David,Fozard, John,Fullerton, Joe,Gosling, Martin,Hatto, Julia,Janus, Diana,Jones, Darryl,Jordan, Lynne,Lewis, Christine,Maas, Janet,McCarthy, Clive,Mercer, Mark,Oakman, Helen,Press, Neil,Profit, Rachel,Schuerch, Friedrich,Sykes, David,Taylor, Roger J.,Trifilieff, Alexandre,Tuffnell, Andrew. "The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1- hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist". . p. 4341 - 4347. Retrieved 2014/10/15.