2,4-diamino-6-iodopyrimidine

Base Information

• Chemical Name: 2,4-diamino-6-iodopyrimidine
• CAS No.: 727651-44-7
• Molecular Formula: C₄H₅IN₄
• Molecular Weight: 236.015
• Mol file: 727651-44-7.mol

Synonyms:2,4-diamino-6-iodopyrimidine

Chemical Property of 2,4-diamino-6-iodopyrimidine

Chemical Property:

Purity/Quality:

6-iodopyrimidine-2,4-diamine 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-diamino-6-iodopyrimidine

There total 2 articles about 2,4-diamino-6-iodopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-chloro-pyrimidine-2,4-diyldiamine (156-83-2) → 2,4-diamino-6-iodopyrimidine (727651-44-7)

Guidance literature:

With hydrogen iodide; sodium iodide; In acetone; at 50 ℃; for 0.5h;

DOI:10.3987/COM-07-11014

Reference yield:

6-chloro-pyrimidine-2,4-diyldiamine (156-83-2) + hydrogen iodide (10034-85-2) → 2,4-diamino-6-iodopyrimidine (727651-44-7)

Guidance literature:

Reference yield: 89.0%

2,4-diamino-6-iodopyrimidine (727651-44-7) + 3-Butyn-1-ol (927-74-2) → 2,4-diamino-6-(4-hydroxybut-1-yn-1-yl)pyrimidine (727651-51-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2004.04.035

upstream raw materials:

6-chloro-pyrimidine-2,4-diyldiamine

hydrogen iodide

Downstream raw materials:

2,4-diaminopyrimidine

2,4-diamino-6-(4-hydroxybut-1-yn-1-yl)pyrimidine

Refernces

• 1、 Hocková, Dana,Holy, Antonín,Masojídková, Milena,Votruba, Ivan. "An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6- iodopyrimidine and 2-amino-4,6-dichloropyrimidine". . p. 4983 - 4987. Retrieved 2007/10/03.