O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)&

Base Information

• Chemical Name: O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)&
• CAS No.: 92451-00-8
• Molecular Formula: C₁₉H₃₂N₂O₁₀
• Molecular Weight: 448.47
• Mol file: 92451-00-8.mol

Synonyms:O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)&;O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)-O’METHYL-PEG 5’000;O-((N-SUCCINIMIDYL)SUCCINYLAMINOETHYL)- O’-METHYL-PEG 2’000;O-Methyl-O渭-[(N-succinimidyl)succinyl-aminoethyl]polyethylene glycol 5渭000, O-Methyl-O渭-[2-(succinylamino)-ethyl]polyethylene glycol 5渭000 N-succinimidyl ester;O-Methyl-O渭-[(N-succinimidyl)succinyl-aminoethyl]polyethylene glycol 2渭000, O-Methyl-O渭-[2-(succinylamino)-ethyl]polyethylene glycol 2渭000 N-succinimidyl ester

Chemical Property of O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)&

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol 2′000 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)&

There total 7 articles about O-((N-SUCCINIMIDYL)SUCCINYL-AMINOETHYL)& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 18-oxo-2,5,8,11,14-pentaoxa-17-azahenicosan-21-oic acid (92450-99-2) → C19H32N2O10 (92451-00-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dimethoxyethane; dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01153

Reference yield:

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → C19H32N2O10 (92451-00-8)

Guidance literature:

Multi-step reaction with 7 steps

1: triethylamine; dmap / dichloromethane / 8 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 11.5 h / 80 °C / Inert atmosphere

5: hydrogen; palladium on activated charcoal / methanol / 2 h / 20 °C

6: triethylamine / dichloromethane / 15.5 h / 20 °C / Inert atmosphere

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; 1,2-dimethoxyethane / 2 h / 20 °C / Inert atmosphere

With dmap; sodium azide; palladium on activated charcoal; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c01153

Reference yield:

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) → C19H32N2O10 (92451-00-8)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 11.5 h / 80 °C / Inert atmosphere

4: hydrogen; palladium on activated charcoal / methanol / 2 h / 20 °C

5: triethylamine / dichloromethane / 15.5 h / 20 °C / Inert atmosphere

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; 1,2-dimethoxyethane / 2 h / 20 °C / Inert atmosphere

With dmap; sodium azide; palladium on activated charcoal; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c01153

upstream raw materials:

triethylene glucol monomethyl ether

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

3,6,9,12,15-pentaoxahexadecanol

3,6,9,12,15-pentaoxahexadecyl tosylate

Refernces