allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate

Base Information

• Chemical Name: allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate
• CAS No.: 193070-97-2
• Molecular Formula: C₂₄H₃₅NO₆
• Molecular Weight: 433.545
• Mol file: 193070-97-2.mol

Synonyms:allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate

Chemical Property of allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate

There total 2 articles about allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-t-butoxycarbonylamino-4-phenylbutyric acid (101555-61-7) + allyl (2S)-2-Hydroxy-4-methylpentanoate (162465-33-0) → allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate (193070-97-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

→ allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate (193070-97-2)

Guidance literature:

Reference yield:

morpholine (110-91-8,99108-56-2) + tetrakistriphenylpalladium + allyl (2S)-2-[3'-N-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoate (193070-97-2) → (2S)-2-[3'-(tert-Butoxycarbonyl)amino-3'-(R)-benzylpropanoyloxy]-4-methylpentanoic Acid

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

(R)-3-t-butoxycarbonylamino-4-phenylbutyric acid

allyl (2S)-2-Hydroxy-4-methylpentanoate

Refernces

• 1、 Shih, Chuan,Gossett, Lynn S.,Gruber, Joseph M.,Grossman, C. Sue,Andis, Sherri L.,et al.. "Synthesis and Biological Evaluation of Novel Cryptophycin Analogs with Modification in the β-Alanine Region". . p. 69 - 74. Retrieved 2007/10/03.