pteroyl azide

Base Information

• Chemical Name: pteroyl azide
• CAS No.: 197151-79-4
• Molecular Formula: C₁₄H₁₁N₉O₂
• Molecular Weight: 337.3
• Mol file: 197151-79-4.mol

Synonyms:pteroyl azide

Chemical Property of pteroyl azide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of pteroyl azide

There total 19 articles about pteroyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

pteroyl hydrazide (197151-68-1) → pteroyl azide (197151-79-4)

Guidance literature:

With tert.-butylnitrite; potassium thioacyanate; trifluoroacetic acid; at -10 ℃; for 6.5h;

DOI:10.1021/jo010283t

Reference yield: 72.0%

pteroyl hydrazide (197151-68-1) → pteroyl azide (197151-79-4) + N10-nitrosopteroyl azide (197151-80-7)

Guidance literature:

With tert.-butylnitrite; potassium thioacyanate; In trifluoroacetic acid; at -10 ℃; for 4h;

DOI:10.1021/ja971568j

Reference yield: 67.0%

pteroyl hydrazide (197151-68-1) → pteroyl azide (197151-79-4)

Guidance literature:

pteroyl hydrazide; With potassium thioacyanate; trifluoroacetic acid; at -10 - 0 ℃;

With tert.-butylnitrite; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2011.02.014

upstream raw materials:

pteroyl hydrazide

N¹⁰-nitrosopteroyl azide

folic acid

pyrofolic acid

Downstream raw materials:

pteroyl-lys

pteroyl-lys-HYNIC

C₂₅H₃₂N₈O₆

Refernces

• 1、 Bertuzzi, Diego L.,Braga, Carolyne B.,Ornelas, Catia,Perli, Gabriel. "Synthesis, characterization, and anticancer activity of folate γ-ferrocenyl conjugates". . p. 4694 - 4703. Retrieved 2020/04/03.
• 2、 Sodji, Quaovi H.,Kornacki, James R.,McDonald, John F.,Mrksich, Milan,Oyelere, Adegboyega K.. "Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids". . p. 340 - 359. Retrieved 2015/04/27.