α-hydroxy-2-bromoacetophenone

Base Information

• Chemical Name: α-hydroxy-2-bromoacetophenone
• CAS No.: 99233-20-2
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.046
• Mol file: 99233-20-2.mol

Synonyms:α-hydroxy-2-bromoacetophenone

Chemical Property of α-hydroxy-2-bromoacetophenone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Bromophenyl)-2-hydroxyethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-hydroxy-2-bromoacetophenone

There total 10 articles about α-hydroxy-2-bromoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

α-acetoxy-2-bromoacetophenone (102540-16-9) → α-hydroxy-2-bromoacetophenone (99233-20-2)

Guidance literature:

With hydrogenchloride; water; In methanol; at 40 ℃; Inert atmosphere;

DOI:10.1021/jo3005556

Reference yield: 76.0%

2-bromophenyl methyl ketone (2142-69-0) → α-hydroxy-2-bromoacetophenone (99233-20-2)

Guidance literature:

2-bromophenyl methyl ketone; With [bis(acetoxy)iodo]benzene; potassium hydroxide; In methanol; at 20 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 20 ℃; for 12h;

DOI:10.1002/adsc.201500953

Reference yield: 11.7%

ortho-bromobenzaldehyde (6630-33-7) + Glyoxilic acid (298-12-4) → α-hydroxy-2-bromoacetophenone (99233-20-2)

Guidance literature:

With thiamine pyrophosphate; magnesium sulfate; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=6.5;

DOI:10.1021/acscatal.0c04961

upstream raw materials:

1-Bromo-2-iodobenzene

α-acetoxy-2-bromoacetophenone

2-bromophenyl methyl ketone

formaldehyd

Downstream raw materials:

3-(hydroxymethyl)-1H-indazole

1H-Indazole-3-carboxylic acid

(1-(2,4-dichlorobenzyl)-1H-indazol-3-yl)methanol

1-(2,4-dichlorobenzyl)-1H-indazole-3-carbaldehyde

Refernces

• 1、 Chen, Yuehua,Deng, Hao,Gao, Xing,Guo, Hongchao,Jiang, Feng,Wang, Wei,Wu, Yongjun,Zhu, Dongyu. "Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes". . p. 7158 - 7163. Retrieved 2020/10/02.
• 2、 De La Campa, Raquel,Manzano, Rubén,Calleja, Paul,Ellis, Sam R.,Dixon, Darren J.. "Enantioselective Silver-Catalyzed Cascade Synthesis of Fused Lactone and Lactam Oxazolines". supporting information. p. 6033 - 6036. Retrieved 2018/09/27.