phenyl(3-hydroxypropyl)(ethyl)phosphine oxide

Base Information

• Chemical Name: phenyl(3-hydroxypropyl)(ethyl)phosphine oxide
• CAS No.: 94583-69-4
• Molecular Formula: C₁₁H₁₇O₂P
• Molecular Weight: 212.229
• Mol file: 94583-69-4.mol

Synonyms:phenyl(3-hydroxypropyl)(ethyl)phosphine oxide

Chemical Property of phenyl(3-hydroxypropyl)(ethyl)phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl(3-hydroxypropyl)(ethyl)phosphine oxide

There total 3 articles about phenyl(3-hydroxypropyl)(ethyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethylmagnesium bromide (925-90-6) + 2-phenyl-[1,2]oxaphospholane 2-oxide (16324-19-9) → phenyl(3-hydroxypropyl)(ethyl)phosphine oxide (94583-69-4)

Guidance literature:

In diethyl ether; at 0 ℃; Inert atmosphere;

DOI:10.3762/bjoc.11.143

Reference yield:

ethylphenylphosphine (3619-88-3) → phenyl(3-hydroxypropyl)(ethyl)phosphine oxide (94583-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Irradiation

2: aq. H₂O₂ / CHCl₃

With dihydrogen peroxide; In chloroform;

Reference yield:

phenylphosphonous acid dimethyl ester (2946-61-4) → phenyl(3-hydroxypropyl)(ethyl)phosphine oxide (94583-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 h / 150 °C / Inert atmosphere

2: diethyl ether / 0 °C / Inert atmosphere

In diethyl ether;

DOI:10.3762/bjoc.11.143

upstream raw materials:

ethylphenylphosphine

phenylphosphonous acid dimethyl ester

ethylmagnesium bromide

2-phenyl-[1,2]oxaphospholane 2-oxide

Refernces