2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

Base Information

• Chemical Name: 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel
• CAS No.: 162375-26-0
• Molecular Formula: C₅₁H₆₃NO₁₃Si
• Molecular Weight: 926.146
• Mol file: 162375-26-0.mol

Synonyms:2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

There total 6 articles about 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel (162375-26-0)

Guidance literature:

With hydrazine; In Isopropyl acetate; at 20 ℃; for 1h;

Reference yield: 65.0%

2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel (162375-26-0) + 2'-(tert-butyldimethylsilyl)-7-epi-taxol (244614-98-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 1.5h;

DOI:10.1021/np030296x

Reference yield:

taxol (33069-62-4) → 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel (162375-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole; DMAP

2: 79 percent / hydrazine

With 1H-imidazole; dmap; hydrazine;

DOI:10.1016/j.tetlet.2006.02.108

upstream raw materials:

2'-O-(tert-butyldimethylsilyl)paclitaxel

10-deacetylpaclitaxel

tert-butyldimethylsilyl chloride

taxol

Downstream raw materials:

C₅₅H₇₁NO₁₃S₂Si

2'-O-(tert-butyldimethylsilyl)-7-chloroacetyl-10-deacetylpaclitaxel

C₃₉H₄₆O₁₂

C₄₇H₅₃NO₁₄

Refernces

• 1、 -. "THIOLATED PACLITAXELS FOR REACTION WITH GOLD NANOPARTICLES AS DRUG DELIVERY AGENTS". Page/Page column 63. . Retrieved 2009/06/27.
• 2、 -. "Biologically Active Taxane Analogs and Methods of Treatment". Page/Page column 8; sheet 2. . Retrieved 2008/12/08.