Technology Process of (1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate
There total 5 articles about (1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
water; acetonitrile;
at 20 - 77 ℃;
Reflux;
Inert atmosphere;
Industry scale;
- Guidance literature:
-
In
water; acetonitrile;
at 77 ℃;
for 0.5h;
Inert atmosphere;
Resolution of racemate;
DOI:10.1021/ml500283g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 4 h / 0 - 20 °C / Industry scale
2: ammonia / tetrahydrofuran; methanol / 72 h / 70 °C / Sealed the reactor
3: acetonitrile; water / 20 - 77 °C / Reflux; Inert atmosphere; Industry scale
With
ammonia; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;