^tBuPCOP

Base Information

• Chemical Name: ^tBuPCOP
• CAS No.: 1449242-84-5
• Molecular Formula: C₂₃H₄₂OP₂
• Molecular Weight: 396.533
• Mol file: 1449242-84-5.mol

Synonyms:^tBuPCOP

Chemical Property of ^tBuPCOP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ^tBuPCOP

There total 4 articles about ^tBuPCOP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

di(tert-butyl)chlorophosphine (13716-10-4) + (3-hydroxybenzyl)di-tert-butylphosphine (646069-73-0) → tBuPCOP (1449242-84-5)

Guidance literature:

(3-hydroxybenzyl)di-tert-butylphosphine; With sodium hydride; In tetrahydrofuran; for 1.5h; Reflux; Schlenk technique;

di(tert-butyl)chlorophosphine; In tetrahydrofuran; for 2h; Reflux; Schlenk technique;

DOI:10.1021/ja4066392

Reference yield:

m-hydroxybenzyl bromide (74597-04-9) → tBuPCOP (1449242-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetone / 12 h / Reflux; Schlenk technique

1.2: 6 h / 80 °C / Schlenk technique

2.1: sodium hydride / tetrahydrofuran / 1.5 h / Reflux; Schlenk technique

2.2: 2 h / Reflux; Schlenk technique

With sodium hydride; In tetrahydrofuran; acetone;

DOI:10.1021/ja4066392

Reference yield:

3-Hydroxybenzyl alcohol (620-24-6) → tBuPCOP (1449242-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphorus tribromide / Inert atmosphere

2.1: acetone / 20 °C / Reflux; Inert atmosphere

2.2: 6 h / 80 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1.5 h / Reflux; Inert atmosphere

3.2: 2 h / Reflux; Inert atmosphere

With phosphorus tribromide; sodium hydride; In tetrahydrofuran; acetone;

DOI:10.1021/cs400624c

upstream raw materials:

di(tert-butyl)chlorophosphine

(3-hydroxybenzyl)di-tert-butylphosphine

di-tert-butylphosphine

m-hydroxybenzyl bromide

Refernces

• 1、 Dobereiner, Graham E.,Yuan, Jian,Schrock, Richard R.,Goldman, Alan S.,Hackenberg, Jason D.. "Catalytic synthesis of n-alkyl arenes through alkyl group cross-metathesis". supporting information. p. 12572 - 12575. Retrieved 2013/09/23.