Technology Process of N-[(3S,5S)-1-benzyl-5-(hydroxymethyl)pyrrolidin-3-yl]ethanamide
There total 10 articles about N-[(3S,5S)-1-benzyl-5-(hydroxymethyl)pyrrolidin-3-yl]ethanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/ejoc.201101829
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / CH2Cl2 / 19 h / 0 °C
2: tetra-n-butylammonium azide / acetonitrile / 1.58 h / 50 - 60 °C
3: 1.) lithium aluminum hydride, 2.) triethylamine / 1.) THF, room temperature, 3 h, 2.) pyridine, room temperature, 8 h
4: sodium methoxide / methanol / 2.25 h / Ambient temperature
With
lithium aluminium tetrahydride; sodium methylate; tetrabutylammoniun azide; triethylamine;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00403a020
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) lithium aluminum hydride, 2.) triethylamine / 1.) THF, room temperature, 3 h, 2.) pyridine, room temperature, 8 h
2: sodium methoxide / methanol / 2.25 h / Ambient temperature
With
lithium aluminium tetrahydride; sodium methylate; triethylamine;
In
methanol;
DOI:10.1021/jm00403a020