Technology Process of L-Proline, 4-azido-1-(phenylmethyl)-, methyl ester, (4S)-
There total 11 articles about L-Proline, 4-azido-1-(phenylmethyl)-, methyl ester, (4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,4R)-1-benzyl-4-hydroxyproline methyl ester;
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
With
sodium azide;
In
dichloromethane; N,N-dimethyl-formamide;
at 80 ℃;
for 12h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2016.03.116
- Guidance literature:
-
N-tert-butoxycarbonyl-cis-4-azido-L-proline methyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
benzaldehyde;
With
sodium tris(acetoxy)borohydride; acetic acid;
In
dichloromethane;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
2.2: 12 h / 80 °C / Inert atmosphere
With
potassium carbonate; methanesulfonyl chloride; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.03.116