Technology Process of 1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3,5-dimethylisoxazol-4-yl)-2-methyl-1,4-dihydro-4-oxo-1,8-naphthyridine
There total 8 articles about 1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3,5-dimethylisoxazol-4-yl)-2-methyl-1,4-dihydro-4-oxo-1,8-naphthyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methylmagnesium bromide;
In
1,4-dioxane;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2 h / Reflux
2: acetic acid / ethanol / 3 h / 50 - 75 °C
3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C
4: triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / 1,4-dioxane / 4 h / Reflux; Inert atmosphere
5: sodium hydroxide; copper(l) iodide; rac-Pro-OH / dimethyl sulfoxide / 9 h / 100 - 120 °C / Sealed tube
6: methylmagnesium bromide / 1,4-dioxane / 2 h / Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; copper(l) iodide; methylmagnesium bromide; potassium carbonate; acetic acid; triethylamine; rac-Pro-OH; sodium hydroxide;
palladium diacetate;
In
1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: acetic acid / ethanol / 3 h / 50 - 75 °C
2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C
3: triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / 1,4-dioxane / 4 h / Reflux; Inert atmosphere
4: sodium hydroxide; copper(l) iodide; rac-Pro-OH / dimethyl sulfoxide / 9 h / 100 - 120 °C / Sealed tube
5: methylmagnesium bromide / 1,4-dioxane / 2 h / Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; copper(l) iodide; methylmagnesium bromide; potassium carbonate; acetic acid; triethylamine; rac-Pro-OH; sodium hydroxide;
palladium diacetate;
In
1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;