1-(2,6-Dichloropyridin-3-yl)ethanone

Base Information

• Chemical Name: 1-(2,6-Dichloropyridin-3-yl)ethanone
• CAS No.: 412018-50-9
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.029
• Hs Code.: 2933399090
• Mol file: 412018-50-9.mol

Synonyms:1-(2,6-dichloropyridin-3-yl)ethanone;

Chemical Property of 1-(2,6-Dichloropyridin-3-yl)ethanone

Chemical Property:

• Boiling Point: 286.732 °C at 760 mmHg
• PKA: -4.81±0.10(Predicted)
• Flash Point: 127.211 °C
• PSA: 29.96000
• Density: 1.376 g/cm³
• LogP: 2.59100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(2,6-Dichloropyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,6-Dichloropyridin-3-yl)ethanone

There total 5 articles about 1-(2,6-Dichloropyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ro 4808591 (873936-98-2) + methylmagnesium bromide (75-16-1) → 1-(4,6-dichloropyridin-3-yl)ethan-1-one (412018-50-9)

Guidance literature:

Ro 4808591; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; hexane; at -5 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at -5 - 20 ℃;

Reference yield:

methyl magnesium iodide (917-64-6) + Ro 4808591 (873936-98-2) → 1-(4,6-dichloropyridin-3-yl)ethan-1-one (412018-50-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 70 ℃; for 72h;

Reference yield:

2,6-dichloropyridine-3-carboxylic acid (38496-18-3) + methylmagnesium bromide (75-16-1) → 1-(4,6-dichloropyridin-3-yl)ethan-1-one (412018-50-9)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 12h;

upstream raw materials:

2,6-dichloronicotinoyl chloride

Ro 4808591

methylmagnesium bromide

methyl magnesium iodide

Downstream raw materials:

1-(2,6-dichloro-pyridin-3-yl)-ethanol

6-chloro-3-methyl-1H-pyrazolo[3,4-b]pyridine

C₂₃H₂₁FN₄O₅S

1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3,5-dimethylisoxazol-4-yl)-2-methyl-1,4-dihydro-4-oxo-1,8-naphthyridine

Refernces

• 1、 -. "HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES". Paragraph 000591; 000601. . Retrieved 2016/05/02.
• 2、 -. "RING-FUSED COMPOUND". Paragraph 0880-0882. . Retrieved 2014/01/07.