(S)-2-(2-ethylphenyl)propan-1-ol

Base Information

• Chemical Name: (S)-2-(2-ethylphenyl)propan-1-ol
• CAS No.: 1313051-57-8
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.247
• Mol file: 1313051-57-8.mol

Synonyms:(S)-2-(2-ethylphenyl)propan-1-ol

Chemical Property of (S)-2-(2-ethylphenyl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-ethylphenyl)propan-1-ol

There total 6 articles about (S)-2-(2-ethylphenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 2-(2-ethylphenyl)propan-1-ol → (S)-2-(2-ethylphenyl)propan-1-ol (1313051-57-8) + C13H18O2 (1313051-33-0) + C13H18O2 (1313051-35-2) + (R)-2-(2-ethyl-phenyl)-propanol (223651-35-2)

Guidance literature:

With Pseudomonas cepacia lipase; In tert-butyl methyl ether; at 20 ℃; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2011.03.012

Reference yield:

ethyl-benzoic acid methyl ester (50604-01-8) → (S)-2-(2-ethylphenyl)propan-1-ol (1313051-57-8) + C13H18O2 (1313051-33-0) + C13H18O2 (1313051-35-2) + (R)-2-(2-ethyl-phenyl)-propanol (223651-35-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 20 - 40 °C

3.3: 20 - 30 °C

4.1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction

With Pseudomonas cepacia lipase; dimethylsulfide borane complex; toluene-4-sulfonic acid; hydroquinone; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether; benzene;

DOI:10.1016/j.tetasy.2011.03.012

Reference yield:

2-(2-ethyl-phenyl)-propan-2-ol (104174-11-0) → (S)-2-(2-ethylphenyl)propan-1-ol (1313051-57-8) + C13H18O2 (1313051-33-0) + C13H18O2 (1313051-35-2) + (R)-2-(2-ethyl-phenyl)-propanol (223651-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 20 - 40 °C

2.3: 20 - 30 °C

3.1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction

With Pseudomonas cepacia lipase; dimethylsulfide borane complex; toluene-4-sulfonic acid; hydroquinone; In tetrahydrofuran; tert-butyl methyl ether; benzene;

DOI:10.1016/j.tetasy.2011.03.012

upstream raw materials:

vinyl acetate

ethyl-benzoic acid methyl ester

2-(2-ethyl-phenyl)-propan-2-ol

2-ethylbenzoic acid

Refernces