50604-01-8

Basic information

• Product Name: 2-Ethylbenzoic acid
• Synonyms: 2-Ethylbenzoic acid methyl ester
• CAS NO: 50604-01-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 50604-01-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 243.9°C at 760 mmHg
• Flash Point: 109.3°C
• Appearance: /
• Density: 1.025g/cm³
• Vapor Pressure: 0.0313mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 2-Ethylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethylbenzoic acid(50604-01-8)
• EPA Substance Registry System: 2-Ethylbenzoic acid(50604-01-8)

Safety Data

• Hazardous Substances Data: 50604-01-8(Hazardous Substances Data)

Usage

General Description

2-Ethylbenzoic acid, also known as o-tolylic acid, is a chemical compound with the molecular formula C9H10O2. It is a derivative of benzoic acid, with the addition of an ethyl group on the second carbon of the aromatic ring. 2-Ethylbenzoic acid is commonly used as an intermediate in the production of various industrial chemicals, including dyes, pharmaceuticals, and fragrances. It has also been studied for its potential antimicrobial and anti-inflammatory properties. Additionally, this compound is known for its use as a key ingredient in the synthesis of liquid crystalline polymers, which have applications in the production of high-performance materials.

InChI:InChI=1/C10H12O2/c1-3-8-6-4-5-7-9(8)10(11)12-2/h4-7H,3H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 28272-96-0 2-vinylbenzaldehyde 
• 81447-53-2 7,7-Dimethoxybicyclo<4.2.0>octa-1,3,5-triene 
• 612-19-1 2-ethylbenzoic acid 
• 76118-05-3 2-ethylbenzoyl chloride 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 557-20-0 diethylzinc 
• 75-03-6 ethyl iodide 
• 693232-15-4 2-(methoxycarbonyl)phenylzinc iodide 
• 118-90-1 ortho-methylbenzoic acid 
• 34136-59-9 o-ethylbenzonitrile 
• 578-54-1 ortho-ethylaniline 
• 694-80-4 2-bromo-1-chlorobenzene 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 16281-95-1 2-(1-Bromethyl)-benzoesaeuremethylester 
• 92552-45-9 2-phenyl-3-methylisoindolin-1-one 
• 4702-34-5 isochroman-1-one 
• 3413-14-7 (S)-3-methylisobenzofuran-1(3H)-one 
• 3413-14-7 (R)-3-methylisobenzofuran-1(3H)-one 
• 1313051-57-8 (S)-2-(2-ethylphenyl)propan-1-ol 
• 1313051-33-0 C₁₃H₁₈O₂ 
• 1313051-35-2 C₁₃H₁₈O₂ 
• 223651-35-2 (R)-2-(2-ethyl-phenyl)-propanol 
• 104174-11-0 2-(2-ethyl-phenyl)-propan-2-ol 
• 593270-22-5 2-bromo-1-(2-ethyl-phenyl)-ethanone 

Relevant articles and documents

Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling

Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles as well as aryl Grignard reagents with sp3-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.

Nickel-catalyzed direct alkynylation of C(sp2)-H bonds of amides: An "inverse Sonogashira strategy" to ortho-alkynylbenzoic acids

Nickel-catalyzed direct alkynylation of C(sp2)-H bonds of amides using commercially available, inexpensive 8-aminoquinoline as a removable bidentate directing group is described. The present ortho-alkynylation has a broad substrate scope, funct

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS

The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can a