4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal

Base Information

• Chemical Name: 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal
• CAS No.: 144024-32-8
• Molecular Formula: C₁₅H₁₅NO₄S
• Molecular Weight: 305.354
• Mol file: 144024-32-8.mol

Synonyms:4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal

Chemical Property of 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal

There total 7 articles about 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-<4-(methylphenyl)sulfonylaminomethylene>-1,1,7,7-tetramethoxy-4-heptanone (147189-48-8) → 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal (144024-32-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 70 ℃; for 0.5h;

DOI:10.1248/cpb.40.2358

Reference yield:

1,1,7,7-tetramethoxy-4-heptanol (147189-44-4) → 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal (144024-32-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / Collins' reagent / CH₂Cl₂ / 0.5 h / 0 °C

2: 87 percent / NaH / benzene; dimethylformamide / 14 h / Ambient temperature

3: 75.5 percent / NH₃ gas, NH₄Cl / methanol / 48 h / Ambient temperature

4: 65 percent / NaH / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature

5: 94 percent / 5percent aq. HCl / tetrahydrofuran / 0.5 h / 70 °C

With hydrogenchloride; Collins oxidation agent; ammonia; sodium hydride; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.40.2358

Reference yield:

4-nitroheptanedial (147189-43-3) → 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal (144024-32-8)

Guidance literature:

Multi-step reaction with 6 steps

1: NH₄Cl / methanol / 14 h / Ambient temperature

2: 1.) KOH, 2.) KMnO₄, MgSO₄ / 1.) MeOH, 0 deg C, 25 min, 2.) MeOH, 0 deg C, 30 min

3: 87 percent / NaH / benzene; dimethylformamide / 14 h / Ambient temperature

4: 75.5 percent / NH₃ gas, NH₄Cl / methanol / 48 h / Ambient temperature

5: 65 percent / NaH / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature

6: 94 percent / 5percent aq. HCl / tetrahydrofuran / 0.5 h / 70 °C

With hydrogenchloride; potassium hydroxide; potassium permanganate; ammonia; sodium hydride; magnesium sulfate; ammonium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.40.2358

upstream raw materials:

3-<4-(methylphenyl)sulfonylaminomethylene>-1,1,7,7-tetramethoxy-4-heptanone

1,1,7,7-tetramethoxy-4-heptanol

4-nitroheptanedial

1,1,7,7-tetramethoxy-4-heptanone

Downstream raw materials:

(S)-(-)-1-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-3-(2-propylamino)-2-propanol

3-chloro-2-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-1-propanol

1-chloro-3-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-2-propanol

1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol

Refernces