Technology Process of 5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione
There total 7 articles about 5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cyclopent-1-ene-1,2-dicarboxylic acid;
With
hydrogenchloride; ammonium hydroxide; acetic anhydride;
In
water;
at 20 ℃;
for 12h;
Inert atmosphere;
With
trifluoroacetic anhydride;
at 40 ℃;
for 18h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.ejmech.2017.04.015
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.25h;
DOI:10.1002/ejoc.202000767
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate; lithium chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Molecular sieve
2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 0 - 20 °C
2.2: 0 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C
With
thionyl chloride; palladium diacetate; sodium hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.202000767
