4,5-Dichloro-2-hydroxypyridine

Base Information

• Chemical Name: 4,5-Dichloro-2-hydroxypyridine
• CAS No.: 856965-66-7
• Molecular Formula: C5H3 Cl2 N O
• Molecular Weight: 163.991
• Hs Code.: 2933399090
• Mol file: 856965-66-7.mol

Synonyms:2-Pyridinol,4,5-dichloro- (5CI)

Chemical Property of 4,5-Dichloro-2-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.0311mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 244°C at 760 mmHg
• Flash Point: 101.4°C
• PSA: 33.12000
• Density: 1.52g/cm³
• LogP: 2.09400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4,5-Dichloropyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Dichloro-2-hydroxypyridine

There total 2 articles about 4,5-Dichloro-2-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

2,3,5-trichloropyridine (55934-01-5) → 4,5-dichloro-2-hydroxypyridine (856965-66-7)

Guidance literature:

With sodium hydroxide; In methanol; water; for 3h; Temperature; Solvent; Cooling with ice;

Reference yield:

4,5-dichloro-2-aminopyridine (188577-68-6) → 2,3,5-trichloropyridine (55934-01-5) + C5H3Cl2NO (856965-66-7)

Guidance literature:

4,5-dichloro-2-aminopyridine; With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃;

With ammonium hydroxide; In water;

Reference yield:

4,5-dichloro-2-hydroxypyridine (856965-66-7) → 2,3,5-trichloropyridine (55934-01-5)

Guidance literature:

With trichlorophosphate; at 130 ℃;

upstream raw materials:

2,3,5-trichloropyridine

4,5-dichloro-2-aminopyridine

Downstream raw materials:

5-Chloro-2,4-dihydroxypyridine

2,3,5-trichloropyridine

2,4-dibromo-5-chloropyridine

Refernces

• 1、 -. "3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS". Page/Page column 66-67. . Retrieved 2010/11/05.