4,5-Dichloropyridin-2-amine

Base Information

• Chemical Name: 4,5-Dichloropyridin-2-amine
• CAS No.: 188577-68-6
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.006
• Hs Code.: 2933399090
• European Community (EC) Number: 690-426-9
• DSSTox Substance ID: DTXSID20444624
• Wikidata: Q72435770
• Mol file: 188577-68-6.mol

Synonyms:4,5-dichloropyridin-2-amine;188577-68-6;2-amino-4,5-dichloropyridine;4,5-dichloro-2-pyridinamine;2-PYRIDINAMINE, 4,5-DICHLORO-;MFCD07437842;SCHEMBL207537;SCHEMBL8212645;DTXSID20444624;CRRAQLWJVYODCL-UHFFFAOYSA-N;AMY10087;AKOS006346244;AB41930;AC-5151;CCG-206402;CS-W006380;PS-5558;SY042008;2-Amino-4,5-dichloropyridine, AldrichCPR;FT-0645376;FT-0656971;EN300-85867;A813244;W-206377;Z1201624122

Chemical Property of 4,5-Dichloropyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.623
• Boiling Point: 269.768 °C at 760 mmHg
• PKA: 3.63±0.24(Predicted)
• Flash Point: 116.952 °C
• PSA: 38.91000
• Density: 1.498 g/cm³
• LogP: 2.55180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 161.9751535
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4,5-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CN=C1N)Cl)Cl

Technology Process of 4,5-Dichloropyridin-2-amine

There total 5 articles about 4,5-Dichloropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(4,5-dichloropyridin-2-yl)-2,2-dimethylpropanamide (188577-71-1) → 4,5-dichloro-2-aminopyridine (188577-68-6)

Guidance literature:

With hydrogenchloride; for 10h; Heating;

DOI:10.1080/00397919708004207

Reference yield: 85.0%

(4,5-dichloropyridin-2-yl)carbamic acid tert-butyl ester → 4,5-dichloro-2-aminopyridine (188577-68-6)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 10h;

Reference yield: 80.0%

2-Amino-4-chloropyridine (19798-80-2) → 2-amino-3,4-dichloropyridine (188577-69-7) + 2-amino-3,4,5-trichloropyridine (55933-91-0) + 4,5-dichloro-2-aminopyridine (188577-68-6)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In water; 1.) 0 deg C -> room temperature, 2.) room temperature, 4 h;

DOI:10.1080/00397919708004207

upstream raw materials:

2-Amino-4-chloropyridine

N-(4,5-dichloropyridin-2-yl)-2,2-dimethylpropanamide

4-chloro-2-trimethylacetamidopyridine

Downstream raw materials:

5-(5-chloro-4-morpholinopyridin-2-ylamino)pyrazine-2-carbonitrile

Refernces

• 1、 Gudmundsson, Kristjan S.,Hinkley, Jack M.,Brieger, Michael S.,Drach, John C.,Townsend, Leroy B.. "An improved large scale synthesis of 2-amino-4-chloropyridine and its use for the convenient preparation of various polychlorinated 2-aminopyridines". . p. 861 - 870. Retrieved 1997.
• 2、 -. "2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY". Page/Page column 69-70. . Retrieved 2018/03/26.