3,4,5-Trichloropyridin-2-amine

Base Information

• Chemical Name: 3,4,5-Trichloropyridin-2-amine
• CAS No.: 55933-91-0
• Molecular Formula: C5H3 Cl3 N2
• Molecular Weight: 197.451
• Hs Code.: 2933399090
• European Community (EC) Number: 965-876-7
• DSSTox Substance ID: DTXSID60472825
• Wikidata: Q82301993
• Mol file: 55933-91-0.mol

Synonyms:3,4,5-trichloropyridin-2-amine;55933-91-0;2-Amino-3,4,5-trichloropyridine;MFCD08705655;SCHEMBL7911779;DTXSID60472825;AKOS006288814;SB22745;AC-27066;DS-15880;SY042366;CS-0051612;FT-0646326;2-Amino-3,4,5-trichloropyridine, AldrichCPR;EN300-170774;A830863

Chemical Property of 3,4,5-Trichloropyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Boiling Point: 272.683oC at 760 mmHg
• PKA: 2.02±0.10(Predicted)
• Flash Point: 118.715oC
• PSA: 38.91000
• Density: 1.635g/cm3
• LogP: 3.20520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.936181
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4,5-Trichloropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C(=N1)N)Cl)Cl)Cl

Technology Process of 3,4,5-Trichloropyridin-2-amine

There total 7 articles about 3,4,5-Trichloropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Amino-4-chloropyridine (19798-80-2) → 2-amino-3,4-dichloropyridine (188577-69-7) + 2-amino-3,4,5-trichloropyridine (55933-91-0) + 4,5-dichloro-2-aminopyridine (188577-68-6)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In water; 1.) 0 deg C -> room temperature, 2.) room temperature, 4 h;

DOI:10.1080/00397919708004207

Reference yield:

C7H6Cl2N2O2 + C6H3Cl3N2O2 (55934-03-7) + picloram (1918-02-1) → 2-amino-3,4,5-trichloropyridine (55933-91-0)

Guidance literature:

With 1,3-dimethyl-2-imidazolidinone; hydrogenchloride; In water; at 100 - 110 ℃; for 2h; Large scale;

Reference yield:

2-Amino-4-chloropyridine (19798-80-2) → 2-amino-3,4,5-trichloropyridine (55933-91-0)

Guidance literature:

With dihydrogen peroxide; sodium carbonate; In conc HCl; water;

upstream raw materials:

pyridine

2-Amino-4-chloropyridine

3,4,5-trichloro-pyridine-2-carboxylic acid amide

bromine

Downstream raw materials:

3,4,5,6-tetrachloro-pyridin-2-ylamine

2,3,4,5-tetrachloro-pyridine

3,5,6-trichloro-2-pyridinol

Refernces

• 1、 -. "Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents". . . Retrieved 2008/06/13.