6-Bromo-3-nitro-4-quinolinol

Base Information

• Chemical Name: 6-Bromo-3-nitro-4-quinolinol
• CAS No.: 853908-50-6
• Molecular Formula: C9H5BrN2O3
• Molecular Weight: 269.054
• Hs Code.: 2933499090
• Mol file: 853908-50-6.mol

Synonyms:6-Bromo-3-nitroquinolin-4-ol;

Chemical Property of 6-Bromo-3-nitro-4-quinolinol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.749
• Boiling Point: 389.339 °C at 760 mmHg
• PKA: -0.53±0.50(Predicted)
• Flash Point: 189.266 °C
• PSA: 78.94000
• Density: 1.878 g/cm³
• LogP: 3.13430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

6-Bromo-3-nitro-4-quinolinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-3-nitro-4-quinolinol

There total 13 articles about 6-Bromo-3-nitro-4-quinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.5%

6-bromoquinolin-4-ol (145369-94-4) → 6-bromo-3-nitroquinolin-4-ol (853908-50-6)

Guidance literature:

With nitric acid; propionic acid; for 2h;

Reference yield: 64.0%

(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid (1201643-75-5) → 6-bromo-3-nitroquinolin-4-ol (853908-50-6)

Guidance literature:

With potassium acetate; In acetic anhydride; at 120 ℃; for 3h;

Reference yield: 60.0%

5-bromo-2-((2-nitroethenyl)amino)benzoic acid (853908-49-3) → 6-bromo-3-nitroquinolin-4-ol (853908-50-6)

Guidance literature:

With sodium acetate; acetic anhydride; at 120 ℃; for 2h;

upstream raw materials:

5-bromo-2-((2-nitroethenyl)amino)benzoic acid

acetic anhydride

(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid

5-Bromo-2-aminobenzoic acid

Downstream raw materials:

2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril

C₁₈H₁₂BrN₅O₂S

C₁₈H₁₂BrN₅O₃

C₂₁H₁₆BrN₅O₅

Refernces

• 1、 Chen, Pei,Li, L.,Lin, Guifeng,Qiao, Jingxin,Xia, A.,Xiang, Z.,Yang, Shengyong,Zhang, Guo. "Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors". supporting information. . Retrieved 2019/08/12.
• 2、 -. "1H-[1,2,3]triazolo[4,5-c]quinoline derivative, preparation method and uses thereof". Paragraph 0274; 0275; 0278; 0279. . Retrieved 2018/09/28.