Ethyl5-chlorothiophen-2-ylsulphonylcarbamate

Base Information

• Chemical Name: Ethyl5-chlorothiophen-2-ylsulphonylcarbamate
• CAS No.: 849793-87-9
• Molecular Formula: C7H8 Cl N O4 S2
• Molecular Weight: 269.73
• Hs Code.: 2935009090
• Mol file: 849793-87-9.mol

Synonyms:Carbamicacid, [(5-chloro-2-thienyl)sulfonyl]-, ethyl ester (9CI); Ethyl[(5-chlorothiophen-2-yl)sulfonyl]carbamate;[(5-Chlorothien-2-yl)sulfonyl]carbamic acid ethyl ester

Chemical Property of Ethyl5-chlorothiophen-2-ylsulphonylcarbamate

Chemical Property:

• PSA: 112.58000
• Density: 1.515
• LogP: 3.12150

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl5-chlorothiophen-2-ylsulphonylcarbamate

There total 1 articles about Ethyl5-chlorothiophen-2-ylsulphonylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chlorothiophene-5-sulfonamide (53595-66-7) + chloroformic acid ethyl ester (541-41-3) → (5-chloro-2-thienyl)sulfonylcarbamic acid ethyl ester (849793-87-9)

Guidance literature:

2-chlorothiophene-5-sulfonamide; chloroformic acid ethyl ester; With caesium carbonate; In tetrahydrofuran; at 0 - 20 ℃; for 36h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; pH=~ 1;

Reference yield: 93.0%

(5-chloro-2-thienyl)sulfonylcarbamic acid ethyl ester (849793-87-9) + 3-(4-aminophenyl)-6-fluoro-7-(methylamino)quinazoline-2,4(1H,3H)-dione (936501-00-7) → Elinogrel (936500-94-6)

Guidance literature:

In dimethyl sulfoxide; at 65 ℃; for 15h; Product distribution / selectivity;

Reference yield: 92.0%

(5-chloro-2-thienyl)sulfonylcarbamic acid ethyl ester (849793-87-9) + 3-(4-aminophenyl)-6-fluoro-7-(methylamino)quinazoline-2,4(1H,3H)-dione → Elinogrel (936500-94-6)

Guidance literature:

In acetonitrile; for 36h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

2-chlorothiophene-5-sulfonamide

chloroformic acid ethyl ester

Downstream raw materials:

5-chloro-N-[({4-[4,5-dichloro-7-fluoro-6-(methylamino)-1-oxoisoquinolin-2(1H)-yl]phenyl}amino)carbonyl]thiophene-2-sulfonamide

Elinogrel

5-chloro-N-[({4-(7-benzylamino)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenylamino)carbonyl]thiophene-2-sulfonamide

5-chloro-N-[(4-(7-amino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenylamino)carbonyl]thiophene-2-sulfonamide

Refernces

• 1、 -. "SUBSTITUTED-(QUINAZOLINYL)PHENYL THIOPHENYL-SULFONYLUREAS, METHODS FOR MAKING AND INTERMEDIATES THEREOF". Page/Page column 35. . Retrieved 2010/11/27.