METHYL2-CHLORO-5-FLUORONICOTINATE

Base Information

• Chemical Name: METHYL2-CHLORO-5-FLUORONICOTINATE
• CAS No.: 847729-27-5
• Molecular Formula: C7H5 Cl F N O2
• Molecular Weight: 189.574
• Hs Code.: 2933399090
• Mol file: 847729-27-5.mol

Synonyms:Methyl2-chloro-5-fluoronicotinate

Chemical Property of METHYL2-CHLORO-5-FLUORONICOTINATE

Chemical Property:

• Vapor Pressure: 0.0502mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 235.4°C at 760 mmHg
• PKA: -3.73±0.10(Predicted)
• Flash Point: 96.2°C
• PSA: 39.19000
• Density: 1.386g/cm³
• LogP: 1.66070
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 2-chloro-5-fluoronicotinate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-chloro-5-fluoronicotinate

Technology Process of METHYL2-CHLORO-5-FLUORONICOTINATE

There total 4 articles about METHYL2-CHLORO-5-FLUORONICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

2-chloro-5-fluoronicotinic acid (38186-88-8) + methyl iodide (74-88-4) → 2-chloro-5-fluoronicotinic acid methyl ester (847729-27-5)

Guidance literature:

In acetonitrile; at 60 ℃;

Reference yield: 72.0%

2-chloro-5-fluoronicotinic acid (38186-88-8) + diazomethyl-trimethyl-silane (18107-18-1) → 2-chloro-5-fluoronicotinic acid methyl ester (847729-27-5)

Guidance literature:

In methanol; hexane; dichloromethane; at 0 ℃; for 1h;

Reference yield: 25.0%

methanol (67-56-1) + 2-chloro-5-fluoronicotinic acid (38186-88-8) → 2-chloro-5-fluoronicotinic acid methyl ester (847729-27-5)

Guidance literature:

With sulfuric acid; for 30h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

2-chloro-5-fluoronicotinic acid

diazomethyl-trimethyl-silane

methanol

methyl iodide

Downstream raw materials:

(5-fluoro-2-methoxypyridin- 3-yl)methanol

5-fluoro-2-methoxy-pyridine-3-carboxylic acid

2-chloro-3-hydroxymethyl-5-fluoropyridine

methyl 5-fluoro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinate

Refernces

• 1、 -. "PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS". Paragraph 0511-0512. . Retrieved 2013/10/08.
• 2、 -. "AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF". Page/Page column 82. . Retrieved 2008/12/06.