5-Fluoro-2-methoxynicotinic acid

Base Information

• Chemical Name: 5-Fluoro-2-methoxynicotinic acid
• CAS No.: 884494-82-0
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Hs Code.: 2933399090
• Mol file: 884494-82-0.mol

Synonyms:5-Fluoro-2-methoxynicotinic acid;

Chemical Property of 5-Fluoro-2-methoxynicotinic acid

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 283.716 °C at 760 mmHg
• PKA: 3.02±0.10(Predicted)
• Flash Point: 125.387 °C
• PSA: 59.42000
• Density: 1.387 g/cm³
• LogP: 0.92750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-2-methoxynicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-methoxynicotinic acid

There total 6 articles about 5-Fluoro-2-methoxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-2-methoxypyridine-3-carbaldehyde (351410-62-3) → 5-fluoro-2-methoxy-pyridine-3-carboxylic acid (884494-82-0)

Guidance literature:

With sodium chlorite; aminosulfonic acid; In 1,4-dioxane; water; at 20 ℃; for 0.0833333h;

Reference yield:

2-chloro-5-fluoronicotinic acid methyl ester (847729-27-5) → 5-fluoro-2-methoxy-pyridine-3-carboxylic acid (884494-82-0)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 100 ℃; for 48h;

Reference yield:

3-bromo-5-fluoro-2-methoxypyridine (884494-81-9) → 5-fluoro-2-methoxy-pyridine-3-carboxylic acid (884494-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / 100 °C / 5171.62 Torr

2: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

3: manganese(IV) oxide / ethyl acetate / 20 °C

4: sodium chlorite; aminosulfonic acid / 1,4-dioxane; water / 0.08 h / 20 °C

With manganese(IV) oxide; sodium chlorite; lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; aminosulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;

upstream raw materials:

5-fluoro-2-methoxynicotinic acid methyl ester

(5-fluoro-2-methoxypyridin- 3-yl)methanol

3-bromo-5-fluoro-2-methoxypyridine

5-fluoro-2-methoxypyridine-3-carbaldehyde

Downstream raw materials:

(5-fluoro-2-methoxypyridin- 3-yl)methanol

1-(5-fluoro-2-methoxypyridin-3-yl)ethanone

Refernces

• 1、 -. "MACROCYCLIC COMPOUNDS AS TRK KINASES INHIBITORS". . . Retrieved 2019/10/19.