Multi-step reaction with 10 steps
1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2.1: dihydrogen peroxide; acetic acid / water / 12 h / 20 - 80 °C
3.1: triethylamine / dichloromethane / 0.5 h / 20 °C
3.2: 15 h / 50 °C
4.1: hydrogenchloride; water / 12 h / 80 °C
4.2: pH 8 - 9
5.1: triethylamine / dichloromethane / 18 h / 20 °C
6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / microwave irradiation
7.1: hydrogenchloride; water / 1,4-dioxane / 1.5 h / 90 °C
8.1: potassium carbonate / 1,1-dichloroethane / 100 °C
9.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 60 °C
10.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C
With
hydrogenchloride; lithium hydroxide; water; dihydrogen peroxide; potassium carbonate; acetic acid; triethylamine; HATU;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; 1,2-dimethoxyethane; 1,1-dichloroethane; dichloromethane; water; N,N-dimethyl-formamide;