442129-37-5

Basic information

• Product Name: 2-Pyridinamine, 6-chloro-5-methyl
• Synonyms: 2-Pyridinamine, 6-chloro-5-methyl;2-Pyridinamine,6-chloro-5-methyl-(9CI);6-Chloro-5-methyl-2-pyridinamine;6-chloro-5-methylpyridin-2-amine;6-Chloro-5-Methyl-pyridin-2-ylaMine;6-AMino-2-chloro-3-Methylpyridine;EOS-61005
• CAS NO: 442129-37-5
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.58618
• Product Categories: PYRIDINE
• Mol File: 442129-37-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 90-92 °C
• Boiling Point: 270.805 °C at 760 mmHg
• Flash Point: 117.579 °C
• Appearance: /
• Density: 1.26 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.00±0.37(Predicted)
• CAS DataBase Reference: 2-Pyridinamine, 6-chloro-5-methyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, 6-chloro-5-methyl(442129-37-5)
• EPA Substance Registry System: 2-Pyridinamine, 6-chloro-5-methyl(442129-37-5)

Safety Data

• Hazardous Substances Data: 442129-37-5(Hazardous Substances Data)

Usage

General Description

2-Pyridinamine, 6-chloro-5-methyl is a chemical compound with the molecular formula C6H7ClN2. It is a derivative of pyridine and contains a chlorine and a methyl group attached to the pyridine ring. 2-Pyridinamine, 6-chloro-5-methyl is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of drugs for various medical conditions due to its ability to bind to biological receptors and enzymes. Additionally, it is used as a building block in organic synthesis for the creation of more complex molecules. However, because of its chemical structure, 2-Pyridinamine, 6-chloro-5-methyl should be handled and used with caution to avoid adverse effects on human health and the environment.

Upstream product

• 19230-57-0 2-bromo-3-methylpyridine 1-oxide 
• 358672-65-8 5-bromo-6-chloropyridin-2-ylamine 
• 91668-83-6 2-Chloro-3-methylpyridine N-oxide 
• 141-43-5 ethanolamine 
• 18368-76-8 2 chloro-3-methylpyridine 
• 13061-96-6 dihydroxy-methyl-borane 
• 80364-46-1 N-(6-chloropyridin-2-yl)acetamide 
• 45644-21-1 6-chloropyridin-2-amine 
• 94242-85-0 2,4,4,5,5-pentamethyl-[1,3,2]dioxaborolane 
• 171520-82-4 5-methyl-2-pivaloylaminopyridine N-oxide 
• 86847-78-1 2,2-Dimethyl-N-(5-methyl-2-pyridinyl)propanamide 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 936727-56-9 N-(6-chloro-5-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide 

Downstream Products

• 936727-60-5 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-chloro-5-methylpyridin-2-yl)cyclopropanecarboxamide 
• 1083168-97-1 N-(6-chloro-5-methylpyridin-2-yl)-1-(2,3-dihydro-1H-inden-5-yl)cyclopropanecarboxamide 
• 936727-68-3 N-(6-chloro-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide 
• 1083168-82-4 6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-amine 
• 936727-05-8 Lumacaftor 
• 1083168-51-7 1-(4-chlorophenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-58-4 1-(3-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-98-2 N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)-1-(3-methoxyphenyl)cyclopropanecarboxamide 
• 1083168-50-6 C₂₃H₂₂ClN₃O₂ 
• 1083167-66-1 1-(benzo[d][1,3]dioxol-5-yl)-N-(6'-methoxy-3-methyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-53-9 1-(3-chloro-4-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083167-75-2 1-(2,3-dihydro-1H-inden-5-yl)-N-(5-methyl-6-(6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-52-8 1-(3-chloro-4-methoxyphenyl)-N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083167-74-1 1-(2,3-dihydro-1H-inden-5-yl)-N-(6'-methoxy-3-methyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 

Relevant articles and documents

Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor

A safe and efficient synthesis of 6-chloro-5-methylpyridin-2-amine, a key intermediate for lumacaftor, is described, which avoids the utilization of peroxide. In this four-step sequence, starting from 2-amino-6-chloropyridine, the crucial 5-position methylation was achieved via a Suzuki-Miyaura cross-coupling reaction. By adopting this synthetic route, 6-chloro-5-methylpyridin-2-amine was produced on a hectogram scale with 62.4% overall yield and 99.49% purity.

2 - Chloro -3 - methyl -6 - acyl aminopyridine and its preparation and use (by machine translation)

The invention belongs to the field of pharmaceutical chemistry and chemical synthesis, in particular to the invention belongs to the field of pharmaceutical chemistry and chemical synthesis, in particular relates to a 2 - chloro - 3 - methyl - 6 - acyl aminopyridine and its preparation and use. The invention provides the following the general formula II of said 2 - chloro - 3 - methyl - 6 - acyl amino pyridine or its pharmaceutically acceptable salt, ester, prodrug or solvate thereof, and [...] fibrosis is an important intermediate of the active ingredient. Through formula II compound represented by the general formula IA or IB obtained compound can be directly used for preparing [...] fibrosis drug. The invention provides general formula IA or IB that the synthesis of the compounds has the following advantages: the security, the method is simple, high yield, it is suitable for industrial production. (by machine translation)

Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy

Small heteroaromatic rings are valuable monomers in drug discovery that can enable rapid access to novel and desirable chemical space. Installation of a synthetic handle on a heteroaromatic core may be difficult if steric and electronic factors are not in alignment with the desired transformation. Described are practical routes for the construction of 5-bromo-6-methyl imidazopyrazine (1) as well as 5-bromo and 5-chloro-6-methyl imidazopyridines (2a and 2b), which were developed using electron density surface maps encoded with ionization potential to guide synthetic strategy.