C₂₃H₂₄F₃NO₄

Base Information

• Chemical Name: C₂₃H₂₄F₃NO₄
• CAS No.: 1401624-60-9
• Molecular Formula: C₂₃H₂₄F₃NO₄
• Molecular Weight: 435.443
• Mol file: 1401624-60-9.mol

Synonyms:C₂₃H₂₄F₃NO₄

Chemical Property of C₂₃H₂₄F₃NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₄F₃NO₄

There total 5 articles about C₂₃H₂₄F₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[(tert-butoxycarbonyl)amino]acrylate (55477-80-0) + N'-((4'-trifluoromethylbiphenyl-4-yl)methyl)sulfonic hydrazide (1401624-59-6) → C23H24F3NO4 (1401624-60-9)

Guidance literature:

N'-((4'-trifluoromethylbiphenyl-4-yl)methyl)sulfonic hydrazide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

methyl 2-[(tert-butoxycarbonyl)amino]acrylate; With N-benzyl-N,N,N-triethylammonium chloride; meso-tetraphenylporphyrin iron(III) chloride; In toluene; at 50 ℃; for 96h; Inert atmosphere;

Reference yield:

p-trifluoromethylphenyl bromide (402-43-7) → C23H24F3NO4 (1401624-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2.1: methanol / 0.5 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 96 h / 50 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene;

Reference yield:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (128376-64-7) → C23H24F3NO4 (1401624-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2.1: methanol / 0.5 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 96 h / 50 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene;

upstream raw materials:

p-trifluoromethylphenyl bromide

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

N-tert-butyloxycarbonyl-L-serine methyl ester

methyl 2-[(tert-butoxycarbonyl)amino]acrylate

Downstream raw materials:

(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylate

tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(trifluoromethyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(trifluoromethyl)biphenyl-4-yl)cyclopropyl)butanamide

Refernces