Technology Process of N-(6-(5-(4-methoxyphenylsulfonamido)-6-methylpyridin-3-yl)benzo[d]thiazol-2-yl)acetamide
There total 8 articles about N-(6-(5-(4-methoxyphenylsulfonamido)-6-methylpyridin-3-yl)benzo[d]thiazol-2-yl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; dmap;
In
tetrahydrofuran;
at 65 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/jm1014605
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
2: hydrogenchloride / water / 110 °C / Inert atmosphere
3: water; iron; acetic acid / 1.25 h / 20 °C / Inert atmosphere; Cooling
4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / 1,2-dimethoxyethane; water / 1.33 h / 100 °C / Inert atmosphere
5: pyridine; dmap / tetrahydrofuran / 6 h / 65 °C / Inert atmosphere
With
pyridine; hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; water; iron; sodium hydride; potassium carbonate; acetic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
4: Suzuki coupling;
DOI:10.1021/jm1014605
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap / dichloromethane / 0 - 20 °C / Cooling with ice; Inert atmosphere
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 2.33 h / Inert atmosphere; Heating
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / 1,2-dimethoxyethane; water / 1.33 h / 100 °C / Inert atmosphere
4: pyridine; dmap / tetrahydrofuran / 6 h / 65 °C / Inert atmosphere
With
pyridine; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; potassium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;
3: Suzuki coupling;
DOI:10.1021/jm1014605