5-BROMO-2-METHYLPYRIDIN-3-AMINE

Base Information

• Chemical Name: 5-BROMO-2-METHYLPYRIDIN-3-AMINE
• CAS No.: 914358-73-9
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• Mol file: 914358-73-9.mol

Synonyms:5-BROMO-2-METHYLPYRIDIN-3-AMINE

Chemical Property of 5-BROMO-2-METHYLPYRIDIN-3-AMINE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 108-109℃
• Refractive Index: 1.617
• Boiling Point: 283.478 °C at 760 mmHg
• PKA: 4.53±0.20(Predicted)
• Flash Point: 125.243 °C
• PSA: 38.91000
• Density: 1.593 g/cm³
• LogP: 2.31590
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-5-bromo-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Description: 5-Bromo-2-methylpyridin-3-amine is also named as 3-Amino-5-bromo-2-methylpyridine. It can be converted to 5-bromo-2-methyl-3-pyridinol by diazotization with sodium nitrite in aqueous sulfuric acid. 5-Bromo-2-methyl-3-pyridinol can be used to make brominated dihydropyridines, which are substrates for the palladium catalyzed coupling, a process to produce compounds for the treatment of patients with disorders, such as central nervous system disorders.

Technology Process of 5-BROMO-2-METHYLPYRIDIN-3-AMINE

There total 1 articles about 5-BROMO-2-METHYLPYRIDIN-3-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → 5-bromo-2-methylpyridin-3-ylamine (914358-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

2: hydrogenchloride / water / 110 °C / Inert atmosphere

3: water; iron; acetic acid / 1.25 h / 20 °C / Inert atmosphere; Cooling

With hydrogenchloride; water; iron; sodium hydride; acetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm1014605

Reference yield: 87.0%

5-bromo-2-methylpyridin-3-ylamine (914358-73-9) + C13H13F2NO5 → 4,4-difluorocyclohexyl (5-bromo-2-methylpyridin-3-yl)carbamate

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.114036

Reference yield: 85.0%

5-bromo-2-methylpyridin-3-ylamine (914358-73-9) + benzenesulfonyl chloride (98-09-9) → N-(5-bromo-2-methylpyridin-3-yl)benzenesulfonamide (1083326-24-2)

Guidance literature:

With sodium hydride; at 220 ℃; for 1h;

DOI:10.3390/molecules22040583

upstream raw materials:

5-bromo-2-chloro-3-nitropyridine

Downstream raw materials:

N-(5-bromo-2-methyl-pyridin-3-yl)-methanesulfonamide

5-bromo-3-ethoxy-2-methyl-pyridine

N-(6-(5-(4-methoxyphenylsulfonamido)-6-methylpyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

N-(5-bromo-2-methyl-pyridin-3-yl)-acetamide

Refernces

• 1、 -. "5-Alkynyl-pyridines". . . Retrieved 2013/03/26.
• 2、 -. "PYRAZOLOPIPERIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS". . . Retrieved 2012/07/13.