Technology Process of 4-(6-fluoropyridin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine
There total 4 articles about 4-(6-fluoropyridin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
at 160 ℃;
for 0.5h;
microwave irradiation;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.5 h / 160 °C / microwave irradiation; Sealed tube
With
potassium acetate; sodium hydride; sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C
2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.5 h / 160 °C / microwave irradiation; Sealed tube
With
potassium acetate; sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; 1,2-dimethoxyethane; water;