trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene

Base Information

• Chemical Name: trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene
• CAS No.: 1415221-72-5
• Molecular Formula: C₂₂H₂₃N₅O₅
• Molecular Weight: 437.455
• Mol file: 1415221-72-5.mol

Synonyms:trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene

Chemical Property of trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene

There total 4 articles about trans-N²-phenylacetyl-2,7-diamino-1-aminomitosene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trans-N2-phenylacetyl-2,7-diamino-1-azidomitosene (1415221-71-4) → trans-N2-phenylacetyl-2,7-diamino-1-aminomitosene (1415221-72-5)

Guidance literature:

With pyridine; ammonium hydroxide; triphenylphosphine; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.09.052

Reference yield:

2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) → trans-N2-phenylacetyl-2,7-diamino-1-aminomitosene (1415221-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 0.08 h / 20 °C / Inert atmosphere

2.1: pyridine; methanesulfonyl chloride / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 90 °C / Inert atmosphere

3.1: pyridine; ammonium hydroxide; triphenylphosphine / 20 °C / Inert atmosphere

With pyridine; ammonium hydroxide; methanesulfonyl chloride; triphenylphosphine; 3.1: |Staudinger Azide Reduction;

DOI:10.1016/j.bmcl.2012.09.052

Reference yield:

phenylacetic anhydride (1555-80-2) → trans-N2-phenylacetyl-2,7-diamino-1-aminomitosene (1415221-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 0.08 h / 20 °C / Inert atmosphere

2.1: pyridine; methanesulfonyl chloride / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 90 °C / Inert atmosphere

3.1: pyridine; ammonium hydroxide; triphenylphosphine / 20 °C / Inert atmosphere

With pyridine; ammonium hydroxide; methanesulfonyl chloride; triphenylphosphine; 3.1: |Staudinger Azide Reduction;

DOI:10.1016/j.bmcl.2012.09.052

upstream raw materials:

trans-N²-phenylacetyl-2,7-diamino-1-azidomitosene

2β,7-Diamino-1β-hydroxymitosene

phenylacetic anhydride

cis-N²-phenylacetyl-2,7-diamino-1-hydroxymitosene

Refernces