ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL&

Base Information

• Chemical Name: ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL&
• CAS No.: 807329-97-1
• Molecular Formula: C3H7 Cl2 Mg . Li
• Molecular Weight: 145.241
• Hs Code.: 29319090
• Mol file: 807329-97-1.mol

Synonyms:Magnesate(1-),dichloro(1-methylethyl)-, lithium (9CI)

Chemical Property of ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL&

Chemical Property:

• Boiling Point: 66℃
• Flash Point: -17 °C
• PSA: 0.00000
• Density: 0.951 g/mL at 25 °C
• LogP: -4.64900
• Sensitive.: Air & Moisture Sensitive
• Solubility.: Miscible with ethers and amines.

Purity/Quality:

99%Min. ^*data from raw suppliers

Isopropylmagnesium chloride lithium chloride complex solution 1.3M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C
• Statements: 14/15-19-34-11
• Safety Statements: 16-26-29-33-36/37/39-43-45-8

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Isopropylmagnesium chloride is used in the regioselective functionalization of trisubstituted pyridines, electrophilic amination for preparation of amines and functionalization of cyclopentene derivatives. It is involved in the preparation of 2,3-functionalized furans, benzofurans, and thiophenes. Further, it is used in benzylic Grignards via sulfur-magnesium exchange.

Technology Process of ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL&

There total 4 articles about ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

isopropyl chloride (75-29-6) → TurboGrignard (807329-97-1)

Guidance literature:

With magnesium; lithium chloride; In tetrahydrofuran; at 80 ℃; under 5171.62 Torr; Temperature; Inert atmosphere; Flow reactor;

DOI:10.3762/bjoc.16.115

Reference yield:

isopropylmagnesium chloride (1068-55-9) → TurboGrignard (807329-97-1)

Guidance literature:

With lithium chloride; In tetrahydrofuran; at 23 ℃; for 72h;

Reference yield:

isopropyl chloride (75-29-6) + magnesium (7439-95-4) + lithium chloride → TurboGrignard (807329-97-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

upstream raw materials:

isopropyl chloride

magnesium

isopropylmagnesium chloride

Downstream raw materials:

2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide

rac-2-methyl-1-phenylpropan-1-ol

4-methoxyisobutyrophenone

Refernces

• 1、 Adamo, Andrea,Berton, Mateo,McQuade, D. Tyler,Sheehan, Kevin. "Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides". supporting information. p. 1343 - 1356. Retrieved 2020/07/10.
• 2、 Bigall, Nadja C.,Duvinage, Daniel,G?bel, Dominik,Nachtsheim, Boris J.,Rusch, Pascal. "Emission color-tunable oxazol(in)yl-substituted excited-state intramolecular proton transfer (ESIPT)-based luminophores". supporting information. p. 15430 - 15433. Retrieved 2020/12/25.