2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide

Base Information

• Chemical Name: 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide
• CAS No.: 1105707-41-2
• Molecular Formula: C₁₆H₂₄N₂O
• Molecular Weight: 260.379
• Mol file: 1105707-41-2.mol

Synonyms:2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide

Chemical Property of 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide

There total 2 articles about 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

TurboGrignard (807329-97-1) + 2-(N-allyl-N-benzylamino)-N-tert-butoxy-N-methylacetamide (1021452-45-8) → 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide (1105707-41-2)

Guidance literature:

2-(N-allyl-N-benzylamino)-N-tert-butoxy-N-methylacetamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

TurboGrignard; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo9015166

Reference yield: 79.0%

2-(N-allyl-N-benzylamino)-N-tert-butoxy-N-methylacetamide (1021452-45-8) + isopropylmagnesium chloride (1068-55-9) → 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide (1105707-41-2)

Guidance literature:

2-(N-allyl-N-benzylamino)-N-tert-butoxy-N-methylacetamide; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.0166667h; Inert atmosphere;

isopropylmagnesium chloride; With lithium chloride; In tetrahydrofuran; at -78 - 25 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.200800683

upstream raw materials:

2-(N-allyl-N-benzylamino)-N-tert-butoxy-N-methylacetamide

isopropylmagnesium chloride

TurboGrignard

Refernces

• 1、 Hirner, Sebastian,Kirchner, Donata K.,Somfai, Peter. "Synthesis of α-amino acids by umpolung of weinreb amide enolates". supporting information; experimental part. p. 5583 - 5589. Retrieved 2009/05/11.