Technology Process of 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester
There total 7 articles about 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium n-butoxide;
In
tetrahydrofuran; tert-butyl alcohol;
Heating;
DOI:10.1021/jo00059a016
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / toluene / 1 h / Heating
2: 100 percent / H2 / 10percent Pd/C / ethyl acetate; methanol / 4 h
3: 99 percent / LiBH4 / diethyl ether / 15 h / Ambient temperature
4: 87 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.25 h / -60 °C
5: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
6: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
7: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
With
lithium borohydride; oxalyl dichloride; potassium tert-butylate; hydrogen; potassium n-butoxide; dimethyl sulfoxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1021/jo00059a016
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / H2 / 10percent Pd/C / ethyl acetate; methanol / 4 h
2: 99 percent / LiBH4 / diethyl ether / 15 h / Ambient temperature
3: 87 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.25 h / -60 °C
4: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
5: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
6: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
With
lithium borohydride; oxalyl dichloride; potassium tert-butylate; hydrogen; potassium n-butoxide; dimethyl sulfoxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo00059a016
