Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester

Base Information

• Chemical Name: Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester
• CAS No.: 179030-52-5
• Molecular Formula: C₂₄H₂₅ClN₅O₈P
• Molecular Weight: 577.918
• Mol file: 179030-52-5.mol

Synonyms:Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester

Chemical Property of Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester

There total 5 articles about Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) → Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester (179030-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, H₂O / acetonitrile / 0.17 h

2: pyridine, 1-(2-mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 12 h / Ambient temperature

With pyridine; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In acetonitrile;

DOI:10.1021/jm950777g

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester (179030-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, H₂O / acetonitrile / 0.17 h

2: pyridine, 1-(2-mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 12 h / Ambient temperature

With pyridine; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In acetonitrile;

DOI:10.1021/jm950777g

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-phenoxy-ethyl ester (179030-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / acetonitrile / 0.5 h / Ambient temperature

2: pyridine, H₂O / acetonitrile / 0.17 h

3: pyridine, 1-(2-mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 12 h / Ambient temperature

With pyridine; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; triethylamine; In acetonitrile;

DOI:10.1021/jm950777g

upstream raw materials:

3'-azido-2',3'-deoxythymidine

2-Phenoxyethanol

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

2-chlorophenyl dichlorophosphate

Refernces