Thiazolo[4,5-c]pyridin-2-amine

Base Information

• Chemical Name: Thiazolo[4,5-c]pyridin-2-amine
• CAS No.: 89786-54-9
• Molecular Formula: C6H5N3S
• Molecular Weight: 151.192
• Hs Code.: 2934999090
• European Community (EC) Number: 817-221-0
• DSSTox Substance ID: DTXSID20558058
• Nikkaji Number: J2.805.169G
• Wikidata: Q72508299
• Mol file: 89786-54-9.mol

Synonyms:thiazolo[4,5-c]pyridin-2-amine;89786-54-9;[1,3]thiazolo[4,5-c]pyridin-2-amine;2-aminothiazolo[4,5-c]pyridine;SCHEMBL1977093;DTXSID20558058;OSHXRTVCVNSLPD-UHFFFAOYSA-N;thiazolo[4,5-c]pyridine-2-ylamine;MFCD08234813;AKOS009547566;MB05751;SS-3062;AM20061606;CS-0054541;EN300-42292;P10566;A846653;Z425813626

Chemical Property of Thiazolo[4,5-c]pyridin-2-amine

Chemical Property:

• Vapor Pressure: 4.43E-05mmHg at 25°C
• Melting Point: 296oC (DEC.)
• Refractive Index: 1.785
• Boiling Point: 350.3 °C at 760 mmHg
• Flash Point: 165.7 °C
• PSA: 80.04000
• Density: 1.485 g/cm³
• LogP: 1.85470
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 151.02041835
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

98%min ^*data from raw suppliers

Thiazolo[4,5-C]pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1SC(=N2)N

Technology Process of Thiazolo[4,5-c]pyridin-2-amine

There total 7 articles about Thiazolo[4,5-c]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

thiazolo[4,5-c]pyridine (273-75-6) + potassium selenocyanate (3425-46-5) → thiazolo[4,5-c]pyridine-2-ylamine (89786-54-9)

Guidance literature:

With trifluoromethylsulfonic anhydride; [bis(acetoxy)iodo]benzene; iodine; In water; at 110 ℃; for 6h; Sealed tube; Green chemistry;

DOI:10.1016/j.cclet.2021.08.070

Reference yield: 22.0%

4-chloro-3-nitropyridine (13091-23-1) + thiourea (17356-08-0) → thiazolo[4,5-c]pyridine-2-ylamine (89786-54-9)

Guidance literature:

In sulfolane; at 135 ℃; for 1.25h; Microwave irradiation;

DOI:10.1002/jhet.185

Reference yield:

N-(thiazolo[4,5-c]pyridin-2-yl)acetamide (97249-84-8) → thiazolo[4,5-c]pyridine-2-ylamine (89786-54-9)

Guidance literature:

With lithium hydroxide; water; In methanol; at 20 - 50 ℃; for 23.5h;

upstream raw materials:

3-nitro-4-thiocyanato-pyridine

hydrogenchloride

water

N-(thiazolo[4,5-c]pyridin-2-yl)acetamide

Downstream raw materials:

2-chlorothiazolo[4,5-c]pyridine

(S)-4-tert-butyl 1-((S)-1-(2-((Z)-3-butylthiazolo[4,5-c]pyridin-2(3H)-ylidenecarbamoyl)-4-(trifluoromethyl)phenoxy)propan-2-yl) 2-(tert-butoxycarbonylamino)succinate

(3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride

(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6". . . Retrieved 2021/09/04.
• 2、 -. "DERIVATlVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE AND USES THEREFOR". Page/Page column 42. . Retrieved 2009/03/07.