methyl 3-phenylbenzoate

Base Information

• Chemical Name: methyl 3-phenylbenzoate
• CAS No.: 16606-00-1
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.248
• Hs Code.: 2916399090
• Mol file: 16606-00-1.mol

Synonyms:methyl 3-phenylbenzoate

Chemical Property of methyl 3-phenylbenzoate

Chemical Property:

Purity/Quality:

METHYL 3-PHENYLBENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-phenylbenzoate

There total 81 articles about methyl 3-phenylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-phenylbenzoic acid (716-76-7) → methyl 3-phenylbenzoate (16606-00-1)

Guidance literature:

With sulfuric acid; at 0 - 50 ℃;

Reference yield: 100.0%

methyl 3-chlorobenzoate (2905-65-9) + phenylboronic acid (98-80-6) → methyl 3-phenylbenzoate (16606-00-1)

Guidance literature:

With potassium phosphate; N,N-diisopropyl 2-dicyclohexylphosphino-4-phenylbenzamide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 110 ℃; for 1h;

DOI:10.1016/j.tetlet.2004.12.133

Reference yield: 99.0%

methyl 3-bromobenzoate (618-89-3) + phenylboronic acid (98-80-6) → methyl 3-phenylbenzoate (16606-00-1)

Guidance literature:

With caesium carbonate; palladium diacetate; In toluene; at 80 ℃; for 8h;

DOI:10.1021/jo062452l

upstream raw materials:

benzoic acid methyl ester

diazomethane

3-phenylbenzoic acid

3-amino-benzoic acid methyl ester hydrochloride

Downstream raw materials:

3-biphenylylmethyl chloride

3-phenylbenzoyl chloride

N'-(3,5-dibromo-2,4-dihydroxybenzylidene)biphenyl-3-carbohydrazide

3-biphenylcarboxylic acid hydrazide

Refernces

• 1、 Dai, Wei-Min,Zhang, Ye. "A family of simple amide-derived air-stable P,O-ligands for Suzuki cross-coupling of unactivated aryl chlorides". . p. 1377 - 1381. Retrieved 2005.
• 2、 Haddad, Boumediene,Villemin, Didier,Belarbi, El-Habib. "Synthesis of palladium-bidentate complex and its application in Sonogashira and Suzuki coupling reactions". . p. 656 - 661. Retrieved 2014.
• 3、 Wang, Congcong,Zhang, Yu-Fang,Guo, Shimeng,Zhao, Quan,Zeng, Yanping,Xie, Zhicheng,Xie, Xin,Lu, Boxun,Hu, Youhong. "GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes". . p. 941 - 957. Retrieved 2020/11/30.
• 4、 Priebbenow, Daniel L.,Leaver, David J.,Nguyen, Nghi,Cleary, Benjamin,Lagiakos, H. Rachel,Sanchez, Julie,Xue, Lian,Huang, Fei,Sun, Yuxin,Mujumdar, Prashant,Mudududdla, Ramesh,Varghese, Swapna,Teguh, Silvia,Charman, Susan A.,White, Karen L.,Shackleford, David M.,Katneni, Kasiram,Cuellar, Matthew,Strasser, Jessica M.,Dahlin, Jayme L.,Walters, Michael A.,Street, Ian P.,Monahan, Brendon J.,Jarman, Kate E.,Jousset Sabroux, Helene,Falk, Hendrik,Chung, Matthew C.,Hermans, Stefan J.,Downer, Natalie L.,Parker, Michael W.,Voss, Anne K.,Thomas, Tim,Baell, Jonathan B.. "Discovery of acylsulfonohydrazide-derived inhibitors of the lysine acetyltransferase, kat6a, as potent senescence-inducing anti-cancer agents". . p. 4655 - 4684. Retrieved 2020/06/08.