Technology Process of benzyl 2,4-di-O-benzyl-6-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-O-<2,4,6-tri-O-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-β-D-glucopyranosyl>-α-D-glucopyranoside
There total 9 articles about benzyl 2,4-di-O-benzyl-6-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-O-<2,4,6-tri-O-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-β-D-glucopyranosyl>-α-D-glucopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; silver trifluoromethanesulfonate;
In
1,2-dichloro-ethane;
at -15 - -10 ℃;
for 3h;
DOI:10.1016/S0008-6215(82)80007-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Bu2SnO / 1.) benzene, MeOH, reflux, 2.5 h; 2.) DMF, 100-120 deg C, 3.5 h
2: 53 percent / LiAlH4, AlCl3 / diethyl ether; CH2Cl2 / 2 h / Heating
3: 26 percent / powdered molecular sieve 4 A, HgBr2 / 1,2-dichloro-ethane / 3.5 h / 20 °C
4: 81 percent / powdered molecular sieve 4 A, AgOSO2CF3 / 1,2-dichloro-ethane / 3 h / -15 - -10 °C
With
lithium aluminium tetrahydride; aluminium trichloride; 4 A molecular sieve; silver trifluoromethanesulfonate; di(n-butyl)tin oxide; mercury dibromide;
In
diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0008-6215(82)80007-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) TsOH*H2O; 2.) Et3N / dimethylformamide / 2 h / 40 - 45 °C
2: 1.) Bu2SnO / 1.) benzene, MeOH, reflux, 2.5 h; 2.) DMF, 100-120 deg C, 3.5 h
3: 53 percent / LiAlH4, AlCl3 / diethyl ether; CH2Cl2 / 2 h / Heating
4: 26 percent / powdered molecular sieve 4 A, HgBr2 / 1,2-dichloro-ethane / 3.5 h / 20 °C
5: 81 percent / powdered molecular sieve 4 A, AgOSO2CF3 / 1,2-dichloro-ethane / 3 h / -15 - -10 °C
With
lithium aluminium tetrahydride; aluminium trichloride; 4 A molecular sieve; silver trifluoromethanesulfonate; di(n-butyl)tin oxide; toluene-4-sulfonic acid; triethylamine; mercury dibromide;
In
diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(82)80007-4