2-METHOXY-2-METHYL-PROPYLAMINE

Base Information

• Chemical Name: 2-METHOXY-2-METHYL-PROPYLAMINE
• CAS No.: 89282-70-2
• Molecular Formula: C5H13 N O
• Molecular Weight: 103.164
• Hs Code.: 2922199090
• Mol file: 89282-70-2.mol

Synonyms:Propylamine,2-methoxy-2-methyl- (7CI); 2-Methoxy-2-methylpropan-1-amine;2-Methoxy-2-methylpropylamine; 2-Methoxyisobutylamine

Chemical Property of 2-METHOXY-2-METHYL-PROPYLAMINE

Chemical Property:

• Vapor Pressure: 15.76mmHg at 25°C
• Refractive Index: 1.417
• Boiling Point: 119.696°C at 760 mmHg
• PKA: 8.88±0.10(Predicted)
• Flash Point: 23.244°C
• PSA: 35.25000
• Density: 0.851g/cm³
• LogP: 1.07040

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxy-2-methylpropan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-Methoxy-2-methyl-propylamine, also known as tert-butylamine, serves various functions in different fields. In the realm of organic synthesis and chemical manufacturing, it plays a pivotal role as a versatile reagent and building block for the creation of complex organic molecules, contributing to the production of specialty chemicals, pharmaceuticals, and agrochemicals. In the field of analytical chemistry, it can be used as a derivatizing agent for the analysis of various compounds, aiding in the detection and quantification of specific analytes. Additionally, in the production of polymers and plastics, tert-butylamine can serve as a chain transfer agent or catalyst, influencing the molecular weight and properties of the resulting materials. Its applications in organic synthesis, analytical chemistry, and polymer production underscore its significance in driving chemical innovation, supporting precise analysis, and enhancing material properties within these diverse domains.

Technology Process of 2-METHOXY-2-METHYL-PROPYLAMINE

There total 11 articles about 2-METHOXY-2-METHYL-PROPYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-bromo-2-methoxy-2-methylpropane (19752-21-7) + potassium phtalimide (1074-82-4) → 2-methoxyisobutyl amine (89282-70-2)

Guidance literature:

With hydrogenchloride; sodium hydroxide; hydrazine; In N-methyl-acetamide; methanol; chloroform; water;

Reference yield: 30.0%

2-methoxyisobutyl cyanide → 2-methoxyisobutyl amine (89282-70-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Inert atmosphere; Reflux;

DOI:10.1002/ejic.201500756

Reference yield:

methanol (67-56-1) + (2-methyl-1-propen-1-yl)trimethylsilane (18292-39-2) → 2-methoxyisobutyl amine (89282-70-2) + 2-methylallylamin (2878-14-0)

Guidance literature:

With (phthalocyaninato)iron(II); O-pivaloylhydroxylamine trifluoromethanesulfonate salt; at 25 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201507630

upstream raw materials:

α-methoxyisobutyramide

2-methoxy-2-methyl-propionaldehyde oxime

2,2-dimethylaziridine

methanol

Downstream raw materials:

N⁸-(2-methoxy-2-methylpropyl)-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine

N₂-(4-(1-ethyl-1H-pyrazol-4-yl)-2-methoxyphenyl)-N₈-(2-methoxy-2-methylpropyl)pyrido[3,4-d]pyrimidine-2,8-diamine

Refernces

• 1、 Kottelat, Emmanuel,Chabert, Valentin,Crochet, Aurélien,Fromm, Katharina M.,Zobi, Fabio. "Towards Cardiolite-Inspired Carbon Monoxide Releasing Molecules - Reactivity of d4, d5 Rhenium and d6 Manganese Carbonyl Complexes with Isocyanide Ligands". . p. 5628 - 5638. Retrieved 2015/12/23.
• 2、 -. "METHODS FOR PREPARING 2-METHOXYISOBUTYLISONITRILE AND TETRAKIS(2-METHOXYISOBUTYLISONITRILE)COPPER(I) TETRAFLUOROBORATE". Page/Page column 9; 10-11. . Retrieved 2008/06/13.