4-bromo-2-cyclopropylphenol

Base Information

• Chemical Name: 4-bromo-2-cyclopropylphenol
• CAS No.: 1043871-14-2
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.074
• Hs Code.: 2908990000
• Mol file: 1043871-14-2.mol

Synonyms:4-bromo-2-cyclopropylphenol

Chemical Property of 4-bromo-2-cyclopropylphenol

Chemical Property:

• Melting Point: 52 °C
• Boiling Point: 217.1±28.0 °C(Predicted)
• Density: 1.613±0.06 g/cm3(Predicted)

Purity/Quality:

4-Bromo-2-cyclopropylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-cyclopropylphenol

There total 5 articles about 4-bromo-2-cyclopropylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-cyclopropylphenol (10292-60-1) → 4-bromo-2-cyclopropylphenol (1043871-14-2)

Guidance literature:

With bromine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

O-allyl-2-bromophenol (60333-75-7) → 4-bromo-2-cyclopropylphenol (1043871-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -78 °C

1.2: 20 °C

2.1: bromine / dichloromethane / 1 h / 0 °C

With bromine; tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;

Reference yield:

2-hydroxybromobenzene (95-56-7) → 4-bromo-2-cyclopropylphenol (1043871-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 1 h / 20 °C

2.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -78 °C

2.2: 20 °C

3.1: bromine / dichloromethane / 1 h / 0 °C

With bromine; tert.-butyl lithium; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil; pentane;

upstream raw materials:

2-cyclopropylphenol

2-hydroxybromobenzene

O-allyl-2-bromophenol

2-Iodophenol

Downstream raw materials:

C₁₈H₂₉BrOSi

1,2-bis(3-cyclopropyl-4-(difluoromethoxy)phenyl)ethyne

1,2-bis(3-cyclopropyl-4-(difluoromethoxy)phenyl)ethane-1,2-dione

4-bromo-2-cyclopropyl-1-(difluoromethoxy)benzene

Refernces

• 1、 -. "BIARYL KINASE INHIBITORS". Page/Page column 71; 72. . Retrieved 2015/11/02.
• 2、 -. "NEW COMPOUNDS 574". Page/Page column 27. . Retrieved 2010/06/13.