butorphanol-PABA carbamate tert-butyl ester

Base Information

• Chemical Name: butorphanol-PABA carbamate tert-butyl ester
• CAS No.: 1314003-91-2
• Molecular Formula: C₃₃H₄₂N₂O₅
• Molecular Weight: 546.707
• Mol file: 1314003-91-2.mol

Synonyms:butorphanol-PABA carbamate tert-butyl ester

Chemical Property of butorphanol-PABA carbamate tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butorphanol-PABA carbamate tert-butyl ester

There total 2 articles about butorphanol-PABA carbamate tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

tert-butyl 4-isocyanatobenzoate (75294-50-7) + Butorphanol (42408-82-2) → butorphanol-PABA carbamate tert-butyl ester (1314003-91-2)

Guidance literature:

In toluene; Reflux;

Reference yield:

tert-butyl 4-aminobenzoate (18144-47-3) → butorphanol-PABA carbamate tert-butyl ester (1314003-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; toluene; water / 0.25 h / 0 - 20 °C

2: toluene / Reflux

With sodium hydrogencarbonate; In dichloromethane; water; toluene;

Reference yield: 43.0%

butorphanol-PABA carbamate tert-butyl ester (1314003-91-2) + trifluoroacetic acid (76-05-1) → butorphanol-PABA carbamate trifluoroacetate (1314003-34-3)

Guidance literature:

at 20 ℃; for 0.75h;

upstream raw materials:

tert-butyl 4-aminobenzoate

tert-butyl 4-isocyanatobenzoate

Butorphanol

Downstream raw materials:

butorphanol-PABA carbamate trifluoroacetate

Refernces