PYRAZOLO[1,5-A]PYRIDINE-2-CARBALDEHYDE

Base Information

• Chemical Name: PYRAZOLO[1,5-A]PYRIDINE-2-CARBALDEHYDE
• CAS No.: 885275-10-5
• Molecular Formula: C8H6 N2 O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 885275-10-5.mol

Synonyms:H-pyrazolo[1,5-a]pyridine-2-carbaldehyde;Pyrazolo[1,5-a]pyridine-2-carboxaldehyde;1H-Pyrazolo[1,5-a]pyridine-2-carbaldehyde

Chemical Property of PYRAZOLO[1,5-A]PYRIDINE-2-CARBALDEHYDE

Chemical Property:

• Refractive Index: 1.64
• PSA: 34.37000
• Density: 1.24
• LogP: 1.14680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

pyrazolo[1,5-a]pyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRAZOLO[1,5-A]PYRIDINE-2-CARBALDEHYDE

There total 11 articles about PYRAZOLO[1,5-A]PYRIDINE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pyrazolo[1,5-a]pyridin-2-ylmethanol (76943-47-0) → pyrazolo[1,5-a]pyridine-2-carbaldehyde (885275-10-5)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 27.0%

pyrazolo[1,5-a]pyridine-2-carboxylic acid (63237-88-7) → pyrazolo[1,5-a]pyridine-2-carbaldehyde (885275-10-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 ℃; for 0.166667h;

DOI:10.1021/jm701375u

Reference yield:

pyrazolo[1,5-a]pyridine-2-carboxylic acid methoxy(methyl)amide (936546-67-7) → pyrazolo[1,5-a]pyridine-2-carbaldehyde (885275-10-5)

Guidance literature:

pyrazolo[1,5-a]pyridine-2-carboxylic acid methoxy(methyl)amide; With lithium aluminium tetrahydride; In tetrahydrofuran; at -15 ℃; for 3h;

With rochelle salt; at 20 ℃; for 0.166667h;

upstream raw materials:

pyrazolo[1,5-a]pyridine-2-carboxylic acid

pyrazolo[1,5-a]pyridine-2-carboxylic acid methoxy(methyl)amide

pyridine

N-iminopyridinium ylide

Downstream raw materials:

C₂₀H₂₃FN₄O

C₂₀H₂₃FN₄O

2-[4-(4-hydroxyphenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine

C₁₇H₁₈FN₅

Refernces

• 1、 -. "HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES". . . Retrieved 2018/03/09.
• 2、 -. "VIRAL REPLICATION INHIBITORS". . . Retrieved 2013/04/13.